CTDSP2

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2Q5E​
Identifiers
Symbols	CTDSP2 ; OS4; PSR2; SCP2
External IDs	OMIM: 608711 HomoloGene: 128791 GeneCards: CTDSP2 Gene
EC number	3.1.3.16
Gene ontology Molecular function • protein binding • CTD phosphatase activity • metal ion binding Cellular component • nucleoplasm Biological process • negative regulation of protein phosphorylation • protein dephosphorylation • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • cellular protein metabolic process • negative regulation of G1/S transition of mitotic cell cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10106	52468
Ensembl	ENSG00000175215	ENSMUSG00000078429
UniProt	O14595	Q8BX07
RefSeq (mRNA)	NM_005730	NM_001113470
RefSeq (protein)	NP_005721	NP_001106941
Location (UCSC)	Chr 12: 57.82 – 57.85 Mb	Chr 10: 126.98 – 127 Mb
PubMed search

Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 is an enzyme that in humans is encoded by the CTDSP2 gene.^[1][2][3]

Interactions

CTDSP2 has been shown to interact with SNAI1.^[4]

References

1. Su YA, Lee MM, Hutter CM, Meltzer PS (Oct 1997). "Characterization of a highly conserved gene (OS4) amplified with CDK4 in human sarcomas". Oncogene 15 (11): 1289–94. doi:10.1038/sj.onc.1201294. PMID 9315096.
2. Yeo M, Lin PS, Dahmus ME, Gill GN (Jul 2003). "A novel RNA polymerase II C-terminal domain phosphatase that preferentially dephosphorylates serine 5". J Biol Chem 278 (28): 26078–85. doi:10.1074/jbc.M301791200. PMID 12721286.
3. "Entrez Gene: CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2".
4. Wu, Yadi; Evers B Mark; Zhou Binhua P (Jan 2009). "Small C-terminal domain phosphatase enhances snail activity through dephosphorylation". J. Biol. Chem. (United States) 284 (1): 640–8. doi:10.1074/jbc.M806916200. ISSN 0021-9258. PMC 2610500. PMID 19004823.

Further reading

• Su YA, Trent JM, Guan XY, Meltzer PS (1994). "Direct isolation of genes encoded within a homogeneously staining region by chromosome microdissection.". Proc. Natl. Acad. Sci. U.S.A. 91 (19): 9121–5. doi:10.1073/pnas.91.19.9121. PMC 44759. PMID 8090779.
• Beutler E, Gelbart T, West C; et al. (1996). "A strategy for cloning the hereditary hemochromatosis gene.". Blood Cells Mol. Dis. 21 (3): 207–16. doi:10.1006/bcmd.1995.0024. PMID 8673473.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brandenberger R, Wei H, Zhang S; et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Thompson J, Lepikhova T, Teixido-Travesa N; et al. (2006). "Small carboxyl-terminal domain phosphatase 2 attenuates androgen-dependent transcription.". EMBO J. 25 (12): 2757–67. doi:10.1038/sj.emboj.7601161. PMC 1500849. PMID 16724108.

External links

• CTDSP2 human gene location in the UCSC Genome Browser.
• CTDSP2 human gene details in the UCSC Genome Browser.