CTNNBL1

Catenin, beta like 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4CB8​, 4CB9​, 4CBA​, 4HM9​, 4HNM​, 4MFU​, 4MFV​
Identifiers
Symbols	CTNNBL1 ; C20orf33; NAP; P14L; PP8304; dJ633O20.1
External IDs	OMIM: 611537 MGI: 1913892 HomoloGene: 12003 GeneCards: CTNNBL1 Gene
Gene ontology Molecular function • protein binding • enzyme binding Cellular component • Prp19 complex • nucleus • nucleoplasm • spliceosomal complex • cytoplasm • membrane Biological process • mRNA splicing, via spliceosome • apoptotic process • RNA splicing • gene expression • somatic diversification of immunoglobulins • positive regulation of apoptotic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56259	66642
Ensembl	ENSG00000132792	ENSMUSG00000027649
UniProt	Q8WYA6	Q9CWL8
RefSeq (mRNA)	NM_001281495	NM_025680
RefSeq (protein)	NP_001268424	NP_079956
Location (UCSC)	Chr 20: 37.69 – 37.87 Mb	Chr 2: 157.74 – 157.89 Mb
PubMed search

Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene.^[1][2]

The protein encoded by this gene contains an acidic domain, a putative bipartite nuclear localization signal, a nuclear export signal, a leucine-isoleucine zipper, and phosphorylation motifs. In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein interactions. Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess apoptosis-inducing activity.^[2]

References

1. Jabbour L, Welter JF, Kollar J, Hering TM (Mar 2003). "Sequence, gene structure, and expression pattern of CTNNBL1, a minor-class intron-containing gene--evidence for a role in apoptosis". Genomics 81 (3): 292–303. doi:10.1016/S0888-7543(02)00038-1. PMID 12659813.
2. "Entrez Gene: CTNNBL1 catenin, beta like 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Deloukas P, Matthews LH, Ashurst J; et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wan D, Gong Y, Qin W; et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMC 524842. PMID 15498874.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Tsang HT, Connell JW, Brown SE; et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.