CTPS2

CTP synthase 2
Rendering based on PDB 2V4U​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2V4U​, 2VKT​, 3IHL​
Identifiers
Symbols	CTPS2 ; DKFZp686C17207; FLJ43358; MGC32997
External IDs	OMIM: 300380 MGI: 1933185 HomoloGene: 115908 GeneCards: CTPS2 Gene
EC number	6.3.4.2
Gene ontology Molecular function • CTP synthase activity • protein binding • ATP binding Cellular component • mitochondrion • cytosol Biological process • pyrimidine nucleotide metabolic process • glutamine metabolic process • nucleobase-containing small molecule interconversion • 'de novo' CTP biosynthetic process • small molecule metabolic process • nucleobase-containing small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	56474	55936
Ensembl	ENSG00000047230	ENSMUSG00000031360
UniProt	Q9NRF8	P70303
RefSeq (mRNA)	NM_001144002	NM_001168568
RefSeq (protein)	NP_001137474	NP_001162040
Location (UCSC)	Chr X: 16.59 – 16.71 Mb	Chr X: 162.9 – 163.03 Mb
PubMed search

CTP synthase 2 is an enzyme that in humans is encoded by the CTPS2 gene.^[1][2]

The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Two alternatively spliced transcript variants encoding the same protein have been described for this gene.^[2]

References

1. van Kuilenburg AB, Meinsma R, Vreken P, Waterham HR, van Gennip AH (Oct 2000). "Identification of a cDNA encoding an isoform of human CTP synthetase". Biochim Biophys Acta 1492 (2–3): 548–52. doi:10.1016/s0167-4781(00)00141-x. PMID 10899599.
2. "Entrez Gene: CTPS2 CTP synthase II".

Further reading

• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Han GS, Sreenivas A, Choi MG, et al. (2006). "Expression of Human CTP Synthetase in Saccharomyces cerevisiae Reveals Phosphorylation by Protein Kinase A". J. Biol. Chem. 280 (46): 38328–36. doi:10.1074/jbc.M509622200. PMC 1400552. PMID 16179339.
• Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.