CUZD1

CUB and zona pellucida-like domains 1
Identifiers
Symbols	CUZD1 ; ERG-1; UO-44
External IDs	MGI: 1202881 HomoloGene: 7389 GeneCards: CUZD1 Gene
Gene ontology Molecular function • protein binding Cellular component • integral component of membrane • transport vesicle membrane • zymogen granule membrane Biological process • substrate-dependent cell migration, cell attachment to substrate • cell cycle • cell proliferation • trypsinogen activation • cell division Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	50624	16433
Ensembl	ENSG00000138161	ENSMUSG00000040205
UniProt	Q86UP6	P70412
RefSeq (mRNA)	NM_022034	NM_008411
RefSeq (protein)	NP_071317	NP_032437
Location (UCSC)	Chr 10: 122.83 – 122.85 Mb	Chr 7: 131.31 – 131.32 Mb
PubMed search

CUB and zona pellucida-like domain-containing protein 1 is a protein that in humans is encoded by the CUZD1 gene.^[1][2]

References

1. Chen D, Xu X, Zhu LJ, Angervo M, Li Q, Bagchi MK, Bagchi IC (Dec 1999). "Cloning and uterus/oviduct-specific expression of a novel estrogen-regulated gene (ERG1)". J Biol Chem 274 (45): 32215–24. doi:10.1074/jbc.274.45.32215. PMID 10542259.
2. "Entrez Gene: CUZD1 CUB and zona pellucida-like domains 1".

Further reading

• Leong CT, Ong CK, Tay SK, Huynh H (2007). "Silencing expression of UO-44 (CUZD1) using small interfering RNA sensitizes human ovarian cancer cells to cisplatin in vitro.". Oncogene 26 (6): 870–80. doi:10.1038/sj.onc.1209836. PMID 16862170.
• Blanchetot C, Chagnon M, Dubé N; et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets.". Methods 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
• Leong CT, Ng CY, Ong CK; et al. (2004). "Molecular cloning, characterization and isolation of novel spliced variants of the human ortholog of a rat estrogen-regulated membrane-associated protein, UO-44.". Oncogene 23 (33): 5707–18. doi:10.1038/sj.onc.1207754. PMID 15184879.
• Deloukas P, Earthrowl ME, Grafham DV; et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Cayabyab FS, Tsui FW, Schlichter LC (2003). "Modulation of the ERG K+ current by the tyrosine phosphatase, SHP-1.". J. Biol. Chem. 277 (50): 48130–8. doi:10.1074/jbc.M208448200. PMID 12361947.
• Huynh H, Ng CY, Lim KB; et al. (2001). "Induction of UO-44 gene expression by tamoxifen in the rat uterus and ovary.". Endocrinology 142 (7): 2985–95. doi:10.1210/en.142.7.2985. PMID 11416020.