BRCC3

BRCA1/BRCA2-containing complex, subunit 3
Identifiers
Symbols	BRCC3 ; BRCC36; C6.1A; CXorf53
External IDs	OMIM: 300617 MGI: 2389572 HomoloGene: 11530 GeneCards: BRCC3 Gene
EC number	3.1.2.15
Gene ontology Molecular function • ubiquitin-specific protease activity • protein binding • metallopeptidase activity • enzyme regulator activity • polyubiquitin binding • metal ion binding Cellular component • ubiquitin ligase complex • nuclear ubiquitin ligase complex • nucleus • nucleoplasm • BRCA1-A complex • BRISC complex Biological process • double-strand break repair • response to X-ray • response to ionizing radiation • G2 DNA damage checkpoint • positive regulation of DNA repair • regulation of catalytic activity • protein K63-linked deubiquitination • histone H2A K63-linked deubiquitination Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79184	210766
Ensembl	ENSG00000185515	ENSMUSG00000031201
UniProt	P46736	P46737
RefSeq (mRNA)	NM_001018055	NM_001166457
RefSeq (protein)	NP_001018065	NP_001159929
Location (UCSC)	Chr X: 155.07 – 155.12 Mb	Chr X: 75.42 – 75.45 Mb
PubMed search

Lys-63-specific deubiquitinase BRCC36 is an enzyme that in humans is encoded by the BRCC3 gene.^[1][2][3]

Function

This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This protein is also thought to be involved in the cellular response to ionizing radiation and progression through the G2/M checkpoint. Alternative splicing results in multiple transcript variants.^[3]

Interactions

BRCC3 has been shown to interact with BRE,^[2][4] BRCA2,^[2] RAD51,^[2] BRCA1,^[2] P53^[2] and BARD1.^[2]

References

1. Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (Jun 1992). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Human Molecular Genetics 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID 1303175.
2. Dong Y, Hakimi MA, Chen X, Kumaraswamy E, Cooch NS, Godwin AK, Shiekhattar R (Nov 2003). "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair". Molecular Cell 12 (5): 1087–99. doi:10.1016/S1097-2765(03)00424-6. PMID 14636569.
3. "Entrez Gene: BRCC3 BRCA1/BRCA2-containing complex, subunit 3".
4. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

Further reading

• Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (Dec 1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene 8 (12): 3271–6. PMID 8247530.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. Check date values in: |year= / |date= mismatch (help)
• Ambroggio XI, Rees DC, Deshaies RJ (Jan 2004). "JAMM: a metalloprotease-like zinc site in the proteasome and signalosome". PLoS Biology 2 (1): E2. doi:10.1371/journal.pbio.0020002. PMC 300881. PMID 14737182. Check date values in: |year= / |date= mismatch (help)
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Boudreau HE, Broustas CG, Gokhale PC, Kumar D, Mewani RR, Rone JD, Haddad BR, Kasid U (Jan 2007). "Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation". International Journal of Molecular Medicine 19 (1): 29–39. doi:10.3892/ijmm.19.1.29. PMID 17143545.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.