CYB5R4

Cytochrome b5 reductase 4
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3LF5​
Identifiers
Symbols	CYB5R4 ; NCB5OR; cb5/cb5R; dJ676J13.1
External IDs	OMIM: 608343 MGI: 2386848 HomoloGene: 69207 GeneCards: CYB5R4 Gene
EC number	1.6.2.2
Gene ontology Molecular function • cytochrome-b5 reductase activity, acting on NAD(P)H • NAD(P)H oxidase activity • oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor • heme binding • metal ion binding Cellular component • endoplasmic reticulum • perinuclear region of cytoplasm Biological process • detection of oxygen • generation of precursor metabolites and energy • superoxide metabolic process • insulin secretion • glucose homeostasis • response to antibiotic • cell development • oxidation-reduction process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51167	266690
Ensembl	ENSG00000065615	ENSMUSG00000032872
UniProt	Q7L1T6	Q3TDX8
RefSeq (mRNA)	NM_016230	NM_024195
RefSeq (protein)	NP_057314	NP_077157
Location (UCSC)	Chr 6: 83.86 – 83.97 Mb	Chr 9: 87.02 – 87.08 Mb
PubMed search

Cytochrome b5 reductase 4 is an enzyme that in humans is encoded by the CYB5R4 gene.^[1][2]

NCB5OR is a flavohemoprotein that contains functional domains found in both cytochrome b5 (CYB5; MIM 250790) and CYB5 reductase (DIA1; MIM 250800).[supplied by OMIM]^[2]

References

1. Zhu H, Qiu H, Yoon HW, Huang S, Bunn HF (Jan 2000). "Identification of a cytochrome b-type NAD(P)H oxidoreductase ubiquitously expressed in human cells". Proc Natl Acad Sci U S A 96 (26): 14742–7. doi:10.1073/pnas.96.26.14742. PMC 24718. PMID 10611283.
2. "Entrez Gene: CYB5R4 cytochrome b5 reductase 4".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R; et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhu H, Larade K, Jackson TA; et al. (2004). "NCB5OR is a novel soluble NAD(P)H reductase localized in the endoplasmic reticulum.". J. Biol. Chem. 279 (29): 30316–25. doi:10.1074/jbc.M402664200. PMC 3045664. PMID 15131110.
• Wiemann S, Arlt D, Huber W; et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Andersen G, Wegner L, Rose CS; et al. (2005). "Variation in NCB5OR: studies of relationships to type 2 diabetes, maturity-onset diabetes of the young, and gestational diabetes mellitus". Diabetes 53 (11): 2992–7. doi:10.2337/diabetes.53.11.2992. PMC 3044473. PMID 15504981.
• Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mehrle A, Rosenfelder H, Schupp I; et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.