CYC1

Cytochrome c-1
PDB rendering based on 1bcc.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1bcc​, 1be3​, 1bgy​, 1l0l​, 1l0n​, 1ntk​, 1ntm​, 1ntz​, 1nu1​, 1pp9​, 1ppj​, 1sqb​, 1sqp​, 1sqq​, 1sqv​, 1sqx​, 2a06​, 2bcc​, 2fyu​, 3bcc​
Identifiers
Symbols	CYC1 ; MC3DN6; UQCR4
External IDs	OMIM: 123980 MGI: 1913695 HomoloGene: 55617 GeneCards: CYC1 Gene
Gene ontology Molecular function • heme binding • electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity • metal ion binding Cellular component • nucleus • mitochondrion • mitochondrial inner membrane • membrane • integral component of membrane • respiratory chain Biological process • respiratory electron transport chain • response to glucagon • cellular metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1537	66445
Ensembl	ENSG00000179091	ENSMUSG00000022551
UniProt	P08574	Q9D0M3
RefSeq (mRNA)	NM_001916	NM_025567
RefSeq (protein)	NP_001907	NP_079843
Location (UCSC)	Chr 8: 144.1 – 144.1 Mb	Chr 15: 76.34 – 76.35 Mb
PubMed search

Cytochrome c1, heme protein, mitochondrial is a protein that in humans is encoded by the CYC1 gene.^[1]

References

1. "Entrez Gene: CYC1 cytochrome c-1".

Further reading

• Moon HS, Yang JS (2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells.". Mol. Cells 21 (1): 7–20. PMID 16511342.
• Suzuki H, Hosokawa Y, Nishikimi M, Ozawa T (1989). "Structural organization of the human mitochondrial cytochrome c1 gene.". J. Biol. Chem. 264 (3): 1368–74. PMID 2536365.
• Nishikimi M, Ohta S, Suzuki H; et al. (1988). "Nucleotide sequence of a cDNA encoding the precursor to human cytochrome c1". Nucleic Acids Res. 16 (8): 3577. doi:10.1093/nar/16.8.3577. PMC 336517. PMID 2836796.
• Tanaka Y, Ashikari T, Shibano Y; et al. (1988). "Construction of a human cytochrome c gene and its functional expression in Saccharomyces cerevisiae". J. Biochem. 103 (6): 954–61. PMID 2844747.
• Shimomura Y, Nishikimi M, Ozawa T (1986). "Novel purification of cytochrome c1 from mitochondrial Complex III. Reconstitution of antimycin-insensitive electron transfer with the iron-sulfur protein and cytochrome c1". J. Biol. Chem. 260 (28): 15075–80. PMID 2999105.
• Nishikimi M, Suzuki H, Ohta S; et al. (1987). "Isolation of a cDNA clone for human cytochrome c1 from a lambda gt11 expression library". Biochem. Biophys. Res. Commun. 145 (1): 34–9. doi:10.1016/0006-291X(87)91283-6. PMID 3036122.
• Smith HT, Ahmed AJ, Millett F (1981). "Electrostatic interaction of cytochrome c with cytochrome c1 and cytochrome oxidase". J. Biol. Chem. 256 (10): 4984–90. PMID 6262312.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Duncan AM, Ozawa T, Suzuki H, Rozen R (1994). "Assignment of the gene for the cytochrome c1 subunit of the mitochondrial cytochrome bc1 complex (CYC1) to human chromosome 8q24.3". Genomics 19 (2): 400–1. doi:10.1006/geno.1994.1084. PMID 8188279.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Valnot I, Kassis J, Chretien D; et al. (1999). "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency". Hum. Genet. 104 (6): 460–6. doi:10.1007/s004390050988. PMID 10453733.
• Jacotot E, Ferri KF, El Hamel C; et al. (2001). "Control of Mitochondrial Membrane Permeabilization by Adenine Nucleotide Translocator Interacting with HIV-1 Viral Protein R and Bcl-2". J. Exp. Med. 193 (4): 509–19. doi:10.1084/jem.193.4.509. PMC 2195906. PMID 11181702.
• Tafani M, Karpinich NO, Hurster KA; et al. (2002). "Cytochrome c release upon Fas receptor activation depends on translocation of full-length bid and the induction of the mitochondrial permeability transition". J. Biol. Chem. 277 (12): 10073–82. doi:10.1074/jbc.M111350200. PMID 11790791.
• Muthumani K, Hwang DS, Desai BM; et al. (2002). "HIV-1 Vpr induces apoptosis through caspase 9 in T cells and peripheral blood mononuclear cells". J. Biol. Chem. 277 (40): 37820–31. doi:10.1074/jbc.M205313200. PMID 12095993.
• Muthumani K, Zhang D, Hwang DS; et al. (2002). "Adenovirus encoding HIV-1 Vpr activates caspase 9 and induces apoptotic cell death in both p53 positive and negative human tumor cell lines". Oncogene 21 (30): 4613–25. doi:10.1038/sj.onc.1205549. PMID 12096338.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brenner C, Kroemer G (2003). "The mitochondriotoxic domain of Vpr determines HIV-1 virulence". J. Clin. Invest. 111 (10): 1455–7. doi:10.1172/JCI18609. PMC 155055. PMID 12750393.
• Lum JJ, Cohen OJ, Nie Z; et al. (2003). "Vpr R77Q is associated with long-term nonprogressive HIV infection and impaired induction of apoptosis". J. Clin. Invest. 111 (10): 1547–54. doi:10.1172/JCI16233. PMC 155040. PMID 12750404.
• Yuan J, Murrell GA, Trickett A, Wang MX (2003). "Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts". Biochim. Biophys. Acta 1641 (1): 35–41. doi:10.1016/S0167-4889(03)00047-8. PMID 12788227.
• An J, Chen Y, Huang Z (2004). "Critical upstream signals of cytochrome C release induced by a novel Bcl-2 inhibitor". J. Biol. Chem. 279 (18): 19133–40. doi:10.1074/jbc.M400295200. PMID 14966123.