CYTL1

Cytokine-like 1
Identifiers
Symbols	CYTL1 ; C17; C4orf4
External IDs	OMIM: 607930 HomoloGene: 10254 GeneCards: CYTL1 Gene
Gene ontology Molecular function • receptor binding Cellular component • extracellular space Biological process • chondrocyte differentiation • signal transduction • positive regulation of transcription from RNA polymerase II promoter • inner ear development • chondroitin sulfate proteoglycan biosynthetic process • positive regulation of sequence-specific DNA binding transcription factor activity • cartilage homeostasis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	54360	231162
Ensembl	ENSG00000170891	ENSMUSG00000062329
UniProt	Q9NRR1	n/a
RefSeq (mRNA)	NM_018659	NM_001081106
RefSeq (protein)	NP_061129	NP_001074575
Location (UCSC)	Chr 4: 5.01 – 5.02 Mb	Chr 5: 37.74 – 37.74 Mb
PubMed search

Cytokine-like 1 is a protein that in humans is encoded by the CYTL1 gene. ^[1]

Function

C17 is a cytokine-like protein specifically expressed in bone marrow and cord blood mononuclear cells that bear the CD34 (MIM 142230) surface marker[PubMed 10857752]). Functionally, C17 was identified as a secretory protein expressed in CD34+ haemopoietic cells [PMID 10857752]. CYTL1 seems to regulate chondrogenesis and is required for the maintenance of cartilage homeostasis and might, additionally, work as a regulatory factor in embryo implantation in the stage of early pregnancy.^[2]

This family of proteins, C17, is found in vertebrates. Proteins have two conserved sequence motifs: PPTCYSR and DDC.

References

1. "Entrez Gene: Cytokine-like 1". Retrieved 2014-02-01.
2. Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation. PLoS ONE 11(1): e0147424. doi: 10.1371/journal.pone.0147424

Further reading

• Ai, Zhichao; Jing, Wei.; Fang, Li (2016). "Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation.". PLoS One 1 (11): e0147424. PMID 26800213.

• Deng, X; Zhao, H. S.; Peng, Z; Deng, W. W.; Li, N; Guo, S; Shi, T. P. (2011). "Study on the mechanism of C17orf62 induced cell death". Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 43 (2): 168–72. PMID 21503106.
• Tomczak, A; Pisabarro, M. T. (2011). "Identification of CCR2-binding features in Cytl1 by a CCL2-like chemokine model". Proteins: Structure, Function, and Bioinformatics 79 (4): 1277–92. doi:10.1002/prot.22963. PMID 21322034.
• Chao, C; Joyce-Shaikh, B; Grein, J; Moshrefi, M; Raoufi, F; Laface, D. M.; McClanahan, T. K.; Bourne, P. A.; Pierce, R. H.; Gorman, D. M.; Pflanz, S (2011). "C17 prevents inflammatory arthritis and associated joint destruction in mice". PLoS ONE 6 (7): e22256. doi:10.1371/journal.pone.0022256. PMC 3143151. PMID 21799806.
• Chen, X. D.; Xiong, D. H.; Yang, T. L.; Pei, Y. F.; Guo, Y. F.; Li, J; Yang, F; Pan, F; Tan, L. J.; Yan, H; Liu, X. G.; Lei, S. F.; Li, X; Ning, L. L.; Zhu, X. Z.; Levy, S; Kranzler, H. R.; Farrer, L. A.; Gelernter, J; Recker, R. R.; Deng, H. W. (2012). "ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior". Chinese medical journal 125 (6): 1127–34. PMID 22613542.
• Liu, X; Rapp, N; Deans, R; Cheng, L (2000). "Molecular cloning and chromosomal mapping of a candidate cytokine gene selectively expressed in human CD34+ cells". Genomics 65 (3): 283–92. doi:10.1006/geno.2000.6170. PMID 10857752.
• Kwon, Y. J.; Lee, S. J.; Koh, J. S.; Kim, S. H.; Lee, H. W.; Kang, M. C.; Bae, J. B.; Kim, Y. J.; Park, J. H. (2012). "Genome-wide analysis of DNA methylation and the gene expression change in lung cancer". Journal of Thoracic Oncology 7 (1): 20–33. doi:10.1097/JTO.0b013e3182307f62. PMID 22011669.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.