Candidapepsin

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Candidapepsin (EC 3.4.23.24, Candida albicans aspartic proteinase, Candida albicans carboxyl proteinase, Candida albicans secretory acid proteinase, Candida olea acid proteinase, Candida aspartic proteinase, Candida olea aspartic proteinase) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave Leu¹⁵-Tyr, Tyr¹⁶-Leu and Phe²⁴-Phe of insulin B chain. Activates trypsinogen, and degrades keratin

This endopeptidase js present in yeast Candida albicans.

References

↑ Remold, H., Fasold, H. and Staib, F. (1968). "Purification and characterization of a proteolytic enzyme from Candida albicans". Biochim. Biophys. Acta 167: 399–406. doi:10.1016/0005-2744(68)90219-2. PMID 5729955.
↑ Rüchel, R. (1981). "Properties of a purified proteinase from the yeast Candida albicans". Biochim. Biophys. Acta 659: 99–113. doi:10.1016/0005-2744(81)90274-6. PMID 7018586.
↑ Negi, M., Tsuboi, R., Matsui, T. and Ogawa, H. (1984). "Isolation and characterization of proteinase from Candida albicans: substrate specificity". J. Invest. Dermatol. 83: 32–36. doi:10.1111/1523-1747.ep12261656. PMID 6203988.
↑ Lott, T.J., Page, L.S., Boiron, P., Benson, J. and Reiss, E. (1989). "Nucleotide sequence of the Candida albicans aspartyl proteinase gene". Nucleic Acids Res. 17: 1779–1779. doi:10.1093/nar/17.4.1779. PMID 2646602.

External links

Candidapepsin at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: aspartate proteases (EC 3.4.23)

Vertebrate	Pepsin Chymosin Renin Signal peptide peptidase Beta secretase 1 2

Pathogenic	Plasmepsin HIV-1 protease

Plant	Nepenthesin

Cathepsin	D E

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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