Carbonic anhydrase VI

Carbonic anhydrase VI
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3FE4​
Identifiers
Symbols	CA6 ; CA-VI; GUSTIN
External IDs	OMIM: 114780 MGI: 1333786 HomoloGene: 20324 ChEMBL: 3025 GeneCards: CA6 Gene
EC number	4.2.1.1
Gene ontology Molecular function • carbonate dehydratase activity • zinc ion binding Cellular component • extracellular region • extracellular space • cytosol • extracellular exosome Biological process • detection of chemical stimulus involved in sensory perception of bitter taste • one-carbon metabolic process • bicarbonate transport • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	765	12353
Ensembl	ENSG00000131686	ENSMUSG00000028972
UniProt	P23280	P18761
RefSeq (mRNA)	NM_001215	NM_009802
RefSeq (protein)	NP_001206	NP_033932
Location (UCSC)	Chr 1: 8.95 – 8.98 Mb	Chr 4: 150.19 – 150.2 Mb
PubMed search

Carbonic anhydrase 6 (also called 'Gustin') is an enzyme that in humans is encoded by the CA6 gene.^[1][2]

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is abundantly found in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide, though its function in saliva is unknown.^[2] It has been suggested that CA VI participates in the maintenance of appropriate pH homeostasis on tooth surfaces as well as in the mucosa of the gastrointestinal canal.

References

1. White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (Oct 1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenet Cell Genet 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177.
2. "Entrez Gene: CA6 carbonic anhydrase VI".

Further reading

• Nishimori I, FujikawaAdachi K, Onishi S, Hollingsworth MA (1999). "Carbonic anhydrase in human pancreas: hypotheses for the pathophysiological roles of CA isozymes.". Ann. N. Y. Acad. Sci. 880: 5–16. doi:10.1111/j.1749-6632.1999.tb09505.x. PMID 10415846.
• Kivela J, Parkkila S, Parkkila AK; et al. (1999). "Salivary carbonic anhydrase isoenzyme VI.". J. Physiol. (Lond.). 520 Pt 2: 315–20. doi:10.1111/j.1469-7793.1999.t01-1-00315.x. PMC 2269599. PMID 10523402.
• Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas.". Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 33 (1): 68–74. doi:10.1016/s1590-8658(01)80138-9. PMID 11303978.
• Breton S (2002). "The cellular physiology of carbonic anhydrases.". JOP 2 (4 Suppl): 159–64. PMID 11875253.
• Aldred P, Fu P, Barrett G; et al. (1991). "Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry.". Biochemistry 30 (2): 569–75. doi:10.1021/bi00216a035. PMID 1899030.
• Parkkila S, Kaunisto K, Rajaniemi L; et al. (1990). "Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands.". J. Histochem. Cytochem. 38 (7): 941–7. doi:10.1177/38.7.2113069. PMID 2113069.
• Murakami H, Sly WS (1987). "Purification and characterization of human salivary carbonic anhydrase.". J. Biol. Chem. 262 (3): 1382–8. PMID 2433278.
• Sutherland GR, Baker E, Fernandez KE; et al. (1989). "The gene for human carbonic anhydrase VI(CA6) is on the tip of the short arm of chromosome 1.". Cytogenet. Cell Genet. 50 (2-3): 149–50. doi:10.1159/000132746. PMID 2505973.
• Ogawa Y, Hong SS, Toyosawa S; et al. (1993). "Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II.". J. Histochem. Cytochem. 41 (3): 343–51. doi:10.1177/41.3.8429198. PMID 8429198.
• Kivelä J, Parkkila S, Waheed A; et al. (1998). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum.". Clin. Chem. 43 (12): 2318–22. PMID 9439449.
• Thatcher BJ, Doherty AE, Orvisky E; et al. (1998). "Gustin from human parotid saliva is carbonic anhydrase VI.". Biochem. Biophys. Res. Commun. 250 (3): 635–41. doi:10.1006/bbrc.1998.9356. PMID 9784398.
• Leinonen J, Kivelä J, Parkkila S; et al. (1999). "Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle.". Caries Res. 33 (3): 185–90. doi:10.1159/000016515. PMID 10207193.
• Redman RS, Peagler FD, Johansson I (2000). "Immunohistochemical localization of carbonic anhydrases I, II, and VI in the developing rat sublingual and submandibular glands.". Anat. Rec. 258 (3): 269–76. doi:10.1002/(SICI)1097-0185(20000301)258:3<269::AID-AR6>3.0.CO;2-Y. PMID 10705347.
• Leinonen J, Parkkila S, Kaunisto K; et al. (2001). "Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands.". J. Histochem. Cytochem. 49 (5): 657–62. doi:10.1177/002215540104900513. PMID 11304804.
• Karhumaa P, Leinonen J, Parkkila S; et al. (2001). "The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk.". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11604–8. doi:10.1073/pnas.121172598. PMC 58776. PMID 11553764.