Carbonyl cyanide m-chlorophenyl hydrazone
 | |
| Names | |
|---|---|
| IUPAC name
[(3-chlorophenyl)hydrazono]malononitrile | |
| Systematic IUPAC name
[(3-chlorophenyl)hydrazono]propanedinitrile | |
| Identifiers | |
555-60-2  | |
| ChEBI | CHEBI:3259 |
| ChEMBL | ChEMBL224214 |
| ChemSpider | 2504 |
| Jmol interactive 3D | Image |
| KEGG | C11164 |
| MeSH | CCCP |
| PubChem | 2603 |
| |
| |
| Properties | |
| C9H5ClN4 | |
| Molar mass | 204.616 g/mol |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
verify (what is  ?) | |
| Infobox references | |
Carbonyl cyanide m-chlorophenyl hydrazone (CCCP), is a chemical inhibitor of oxidative phosphorylation. It is a nitrile, hydrazone and protonophore. In general, CCCP causes the gradual destruction of living cells and death of the organism.[1][2] The CCCP affects the protein synthesis reactions in seedling mitochondria.[3] CCCP causes an uncoupling of the proton gradient that is established during the normal activity of electron carriers in the electron transport chain. The chemical acts essentially as an ionophore and reduces the ability of ATP synthase to function optimally.
See also
References
- ↑ J.W. Park; S.Y. Lee; J.Y. Yang; H.W. Rho; B.H. Park; S.N. Lim; J.S. Kim; H.R. Kim (1997). "Effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on the dimerization of lipoprotein lipase.". Biochimica et Biophysica Acta 1344 (2): 132–8. doi:10.1016/s0005-2760(96)00146-4. PMID 9030190.
- ↑ D. Gášková; B. Brodská; A. Holoubek; K. Sigler (1999). "Factors and processes involved in membrane potential build-up in yeast: diS-C3(3) assay". The International Journal of Biochemistry & Cell Biology 31 (5): 575–584. doi:10.1016/S1357-2725(99)00002-3.
- ↑ Y.M. Konstantinov; I.V. Subota; A.S. Arziev. "Protein synthesis in mitochondria under different redox conditions". Preprint of the Irkutsk Institute of Plant Physiology and Biochemistry.
This article is issued from Wikipedia - version of the Wednesday, December 16, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.