Carboxylesterase 2

"CES2" redirects here. For the airport in Quebec, see Saint-Esprit Aerodrome.
Carboxylesterase 2
Identifiers
Symbols CES2 ; CE-2; CES2A1; PCE-2; iCE
External IDs OMIM: 605278 MGI: 3648740 HomoloGene: 128645 ChEMBL: 3180 GeneCards: CES2 Gene
EC number 3.1.1.1, 3.1.1.56, 3.1.1.84
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8824 436059
Ensembl ENSG00000172831 ENSMUSG00000091813
UniProt O00748 Q91WG0
RefSeq (mRNA) NM_003869 NM_001272045
RefSeq (protein) NP_003860 NP_001258974
Location (UCSC) Chr 16:
66.93 – 66.95 Mb
Chr 8:
105 – 105.02 Mb
PubMed search

Carboxylesterase 2 is an enzyme that in humans is encoded by the CES2 gene.[1][2][3] It is a member of the alpha/beta fold hydrolase family.[4]

Carboxylesterase 2 is a member of a large multigene family. The enzymes encoded by these genes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. The specific function of this enzyme has not yet been determined; however, it is speculated that carboxylesterases may play a role in lipid metabolism and/or the blood–brain barrier system. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article

|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

  1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
Click on genes, proteins and metabolites below to link to respective articles. [§ 1]
[[File:
IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article
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IrinotecanPathway_WP46359 go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article

|{{{bSize}}}px|alt=Irinotecan Pathway edit]]

Irinotecan Pathway edit

  1. The interactive pathway map can be edited at WikiPathways: "IrinotecanPathway_WP46359".

References

  1. Pindel EV, Kedishvili NY, Abraham TL, Brzezinski MR, Zhang J, Dean RA, Bosron WF (Jun 1997). "Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin". J Biol Chem 272 (23): 14769–75. doi:10.1074/jbc.272.23.14769. PMID 9169443.
  2. Schwer H, Langmann T, Daig R, Becker A, Aslanidis C, Schmitz G (Jun 1997). "Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver". Biochem Biophys Res Commun 233 (1): 117–20. doi:10.1006/bbrc.1997.6413. PMID 9144407.
  3. 1 2 "Entrez Gene: CES2 carboxylesterase 2 (intestine, liver)".
  4. Imai T (Jun 2006). "Human Carboxylesterase Isozymes: Catalytic Properties and Rational Drug Design". Drug Metabolism and Pharmacokinetics 21 (3): 173–185. doi:10.2133/dmpk.21.173. PMID 16858120.

Further reading


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