Carboxynorspermidine synthase

Carboxynorspermidine synthase
Identifiers
EC number	1.5.1.43
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Carboxynorspermidine synthase (EC 1.5.1.43, carboxynorspermidine dehydrogenase, carboxyspermidine dehydrogenase, CASDH, CANSDH) is an enzyme with systematic name carboxynorspermidine:NADP⁺ oxidoreductase.^[1][2][3] This enzyme catalyses the following chemical reactions

(1) carboxynorspermidine + H₂O + NADP⁺ $\rightleftharpoons$ L-aspartate 4-semialdehyde + propane-1,3-diamine + NADPH + H⁺

(2) carboxyspermidine + H₂O + NADP⁺ $\rightleftharpoons$ L-aspartate 4-semialdehyde + putrescine + NADPH + H⁺

The reaction takes place in the opposite direction.

References

1. Nakao, H., Shinoda, S. and Yamamoto, S. (1991). "Purification and some properties of carboxynorspermidine synthase participating in a novel biosynthetic pathway for norspermidine in Vibrio alginolyticus". J. Gen. Microbiol. 137 (7): 1737–1742. doi:10.1099/00221287-137-7-1737. PMID 1955861.
2. Lee, J., Sperandio, V., Frantz, D.E., Longgood, J., Camilli, A., Phillips, M.A. and Michael, A.J. (2009). "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". J. Biol. Chem. 284: 9899–9907. doi:10.1074/jbc.M900110200. PMC 2665113. PMID 19196710.
3. Hanfrey, C.C., Pearson, B.M., Hazeldine, S., Lee, J., Gaskin, D.J., Woster, P.M., Phillips, M.A. and Michael, A.J. (2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". J. Biol. Chem. 286: 43301–43312. doi:10.1074/jbc.M111.307835. PMC 3234850. PMID 22025614.

External links

• Carboxynorspermidine synthase at the US National Library of Medicine Medical Subject Headings (MeSH)