Carboxypeptidase A1

Carboxypeptidase A1 (pancreatic)
Rendering based on PDB 2V77​.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2V77​, 3FJU​
Identifiers
Symbols	CPA1 ; CPA
External IDs	OMIM: 114850 MGI: 88478 HomoloGene: 55609 IUPHAR: 1587 ChEMBL: 2088 GeneCards: CPA1 Gene
EC number	3.4.17.1
Gene ontology Molecular function • metallocarboxypeptidase activity • zinc ion binding Cellular component • extracellular space Biological process • proteolysis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1357	109697
Ensembl	ENSG00000091704	ENSMUSG00000054446
UniProt	P15085	Q7TPZ8
RefSeq (mRNA)	NM_001868	NM_025350
RefSeq (protein)	NP_001859	NP_079626
Location (UCSC)	Chr 7: 130.38 – 130.39 Mb	Chr 6: 30.64 – 30.65 Mb
PubMed search

Carboxypeptidase A1 is an enzyme that in humans is encoded by the CPA1 gene.^[1]

Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition.^[1]

References

1. "Entrez Gene: CPA1 carboxypeptidase A1 (pancreatic)".

Further reading

• Catasús L, Villegas V, Pascual R; et al. (1992). "cDNA cloning and sequence analysis of human pancreatic procarboxypeptidase A1.". Biochem. J. 287 (1): 299–303. PMC 1133158. PMID 1417781.
• Stewart EA, Craik CS, Hake L, Bowcock AM (1990). "Human carboxypeptidase A identifies a BglII RFLP and maps to 7q31-qter.". Am. J. Hum. Genet. 46 (4): 795–800. PMC 1683655. PMID 1969228.
• Moulard M, Michon T, Kerfelec B, Chapus C (1990). "Further studies on the human pancreatic binary complexes involving procarboxypeptidase A.". FEBS Lett. 261 (1): 179–83. doi:10.1016/0014-5793(90)80665-6. PMID 2307232.
• Pascual R, Burgos FJ, Salva M; et al. (1989). "Purification and properties of five different forms of human procarboxypeptidases.". Eur. J. Biochem. 179 (3): 609–16. doi:10.1111/j.1432-1033.1989.tb14590.x. PMID 2920728.
• Honey NK, Sakaguchi AY, Lalley PA; et al. (1986). "Assignment of the gene for carboxypeptidase A to human chromosome 7q22----qter and to mouse chromosome 6.". Hum. Genet. 72 (1): 27–31. doi:10.1007/BF00278813. PMID 3455919.
• Velculescu VE, Zhang L, Vogelstein B, Kinzler KW (1995). "Serial analysis of gene expression.". Science 270 (5235): 484–7. doi:10.1126/science.270.5235.484. PMID 7570003.
• Laethem RM, Blumenkopf TA, Cory M; et al. (1996). "Expression and characterization of human pancreatic preprocarboxypeptidase A1 and preprocarboxypeptidase A2.". Arch. Biochem. Biophys. 332 (1): 8–18. doi:10.1006/abbi.1996.0310. PMID 8806703.
• Bonora E, Bacchelli E, Levy ER; et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region.". Mol. Psychiatry 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• The MEROPS online database for peptidases and their inhibitors: M14.001