Carlactone synthase

Carlactone synthase
Identifiers
EC number	1.13.11.69
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Carlactone synthase (EC 1.13.11.69, CCD8 (gene), MAX4 (gene), NCED8 (gene)) is an enzyme with systematic name 9-cis-10'-apo-beta-carotenal:O2 oxidoreductase (14,15-cleaving, carlactone-forming).^[1][2][3] This enzyme catalyses the following chemical reaction

9-cis-10'-apo-beta-carotenal + 2 O₂ $\rightleftharpoons$ carlactone + (2E,4E,6E)-7-hydroxy-4-methylhepta-2,4,6-trienal

Carlactone synthase contains Fe²⁺.

References

1. Sorefan, K., Booker, J., Haurogne, K., Goussot, M., Bainbridge, K., Foo, E., Chatfield, S., Ward, S., Beveridge, C., Rameau, C. and Leyser, O. (2003). "MAX4 and RMS1 are orthologous dioxygenase-like genes that regulate shoot branching in Arabidopsis and pea". Genes Dev. 17 (12): 1469–1474. doi:10.1101/gad.256603. PMC 196077. PMID 12815068.
2. Schwartz, S.H., Qin, X. and Loewen, M.C. (2004). "The biochemical characterization of two carotenoid cleavage enzymes from Arabidopsis indicates that a carotenoid-derived compound inhibits lateral branching". J. Biol. Chem. 279 (45): 46940–46945. doi:10.1074/jbc.M409004200. PMID 15342640.
3. Alder, A., Jamil, M., Marzorati, M., Bruno, M., Vermathen, M., Bigler, P., Ghisla, S., Bouwmeester, H., Beyer, P. and Al-Babili, S. (2012). "The path from β-carotene to carlactone, a strigolactone-like plant hormone". Science 335 (6074): 1348–1351. doi:10.1126/science.1218094. PMID 22422982.

External links

• Carlactone synthase at the US National Library of Medicine Medical Subject Headings (MeSH)