Carlson Curve

Total cost of sequencing a human genome over time as calculated by the NHGRI.

The Carlson Curve is a term coined by The Economist^[1] to describe the biotechnological equivalent of Moore's law, and is named after author Rob Carlson.^[2] Carlson predicted that the doubling time of DNA sequencing technologies (measured by cost and performance) would be at least as fast as Moore's law.^[3] Carlson Curves illustrate the rapid (in some cases above exponential growth) decreases in cost, and increases in performance, of a variety of technologies, including DNA sequencing, DNA synthesis and a range of physical and computational tools used in protein production and in determining protein structures.

Moore's Law started being profoundly out-paced in January 2008 when the centers transitioned from Sanger sequencing to newer DNA sequencing technologies :^[4]

• 454 sequencing (average read length=300-400 bases): 10-fold
• Illumina and SOLiD sequencing (average read length=50-100 bases): 30-fold.

References

1. "Life 2.0.". The Economist. August 31, 2006.
2. Robert H. Carlson (April 2011). Biology Is Technology : The Promise, Peril, and New Business of Engineering Life. Cambridge, MA: Harvard University Press.
3. Robert Carlson (September 2003). "The Pace and Proliferation of Biological Technologies". Biosecurity and Bioterrorism: Biodefense Strategy, Practice, and Science (Mary Ann Liebert, Inc.) 1 (3: 203-214). doi:10.1089/153871303769201851.
4. "DNA Sequencing Costs". National Human Genome Research Institute.