Carnosol

Carnosol

Identifiers
CAS Number	5957-80-2
ChemSpider	390568
Jmol interactive 3D	Image
PubChem	442009
InChI InChI=1S/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 Key: XUSYGBPHQBWGAD-PJSUUKDQSA-N InChI=1/C20H26O4/c1-10(2)11-8-12-13-9-14-19(3,4)6-5-7-20(14,18(23)24-13)15(12)17(22)16(11)21/h8,10,13-14,21-22H,5-7,9H2,1-4H3/t13-,14-,20+/m0/s1 Key: XUSYGBPHQBWGAD-PJSUUKDQBN
SMILES CC(C)C1=CC2=C(C(=C1O)O)[C@@]34CCCC([C@@H]3C[C@@H]2OC4=O)(C)C
Properties
Chemical formula	C20H26O4
Molar mass	330.42 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Carnosol is a phenolic diterpene found in the herbs rosemary (Rosmarinus officinalis)^[1] and Mountain desert sage (Salvia pachyphylla).^[2]

It has been studied in-vitro for anti-cancer effects in various cancer cell types.^[3]

See also

• Carnosic acid
• List of phytochemicals in food

References

1. Ai-Hsiang Lo, Yu-Chih Liang, Shoei-Yn Lin-Shiau, Chi-Tang Ho and Jen-Kun Lin (2002). "Carnosol, an antioxidant in rosemary, suppresses inducible nitric oxide synthase through down-regulating nuclear factor-κB in mouse macrophages". Carcinogenesis 23 (6): 983–991. doi:10.1093/carcin/23.6.983. PMID 12082020.
2. Ivan C. Guerrero, Lucia S. Andres, Leticia G. Leon, Ruben P. Machin, Jose M. Padron, Javier G. Luis, and Jose Delgadillo (2006). "Abietane Diterpenoids from Salvia pachyphylla and S. clevelandii with Cytotoxic Activity against Human Cancer Cell Lines". J. Nat. Prod. 69 (12): 1803–1805. doi:10.1021/np060279i. PMID 17190465.
3. Carnosol: A promising anti-cancer and anti-inflammatory agent. Johnson 2011 doi=10.1016/j.canlet.2011.02.005