Cell adhesion molecule 1

Cell adhesion molecule 1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3BIN​, 4H5S​
Identifiers
Symbols	CADM1 ; BL2; IGSF4; IGSF4A; NECL2; Necl-2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; sgIGSF; synCAM1
External IDs	OMIM: 605686 MGI: 1889272 HomoloGene: 8641 GeneCards: CADM1 Gene
Gene ontology Molecular function • receptor activity • receptor binding • protein binding • PDZ domain binding • protein homodimerization activity • cell adhesion molecule binding Cellular component • plasma membrane • integral component of plasma membrane • cell-cell junction • cell-cell adherens junction • synaptic vesicle • basolateral plasma membrane • dendrite • varicosity • extracellular exosome • cell body fiber Biological process • liver development • T cell mediated cytotoxicity • apoptotic process • homophilic cell adhesion via plasma membrane adhesion molecules • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules • spermatogenesis • synapse assembly • brain development • cell recognition • unidimensional cell growth • calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules • cell differentiation • cell junction assembly • adherens junction organization • susceptibility to natural killer cell mediated cytotoxicity • cell-cell junction organization • positive regulation of natural killer cell mediated cytotoxicity • positive regulation of cytokine secretion • activated T cell proliferation • detection of stimulus • bone development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	23705	54725
Ensembl	ENSG00000182985	ENSMUSG00000032076
UniProt	Q9BY67	Q8R5M8
RefSeq (mRNA)	NM_001098517	NM_001025600
RefSeq (protein)	NP_001091987	NP_001020771
Location (UCSC)	Chr 11: 115.17 – 115.5 Mb	Chr 9: 47.53 – 47.86 Mb
PubMed search

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.^[1][2]

Model organisms

Cadm1 knockout mouse phenotype

Characteristic	Phenotype
Homozygote viability	Normal
Fertility	Abnormal
Body weight	Normal
Anxiety	Normal
Neurological assessment	Normal
Grip strength	Normal
Hot plate	Normal
Dysmorphology	Normal
Rotarod	Normal
Non-Invasive Blood Pressure	Normal
Prepulse inhibition	Normal
Indirect calorimetry	Normal
Glucose tolerance test	Normal
Auditory brainstem response	Normal
DEXA	Normal
Radiography	Normal
Body temperature	Normal
Eye morphology	Normal
Clinical chemistry	Normal
Haematology	Normal
Micronucleus test	Normal
Heart weight	Normal
Tail epidermis wholemount	Normal
Brain histopathology	Normal
Salmonella infection	Normal[3]
Citrobacter infection	Normal[4]
All tests and analysis from[5]

Model organisms have been used in the study of CADM1 function. A conditional knockout mouse line, called Cadm1^tm1.2Brd[6] was generated.^[7] Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.^[5][8] Twenty six tests were carried out on homozygous mutant mice and one significant abnormality was observed: males were infertile.^[5] Further analysis showed spermatogenesis had arrested in these mice.^[7]

Interactions

Cell adhesion molecule 1 has been shown to interact with EPB41L3.^[9]

See also

• Cell adhesion molecule

References

1. Gomyo H, Arai Y, Tanigami A, Murakami Y, Hattori M, Hosoda F, Arai K, Aikawa Y, Tsuda H, Hirohashi S, Asakawa S, Shimizu N, Soeda E, Sakaki Y, Ohki M (Feb 2000). "A 2-Mb sequence-ready contig map and a novel immunoglobulin superfamily gene IGSF4 in the LOH region of chromosome 11q23.2". Genomics 62 (2): 139–46. doi:10.1006/geno.1999.6001. PMID 10610705.
2. "Entrez Gene: CADM1 cell adhesion molecule 1".
3. "Salmonella infection data for Cadm1". Wellcome Trust Sanger Institute.
4. "Citrobacter infection data for Cadm1". Wellcome Trust Sanger Institute.
5. Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
6. "Mouse Genome Informatics".
7. Van Der Weyden, L.; Arends, M. J.; Chausiaux, O. E.; Ellis, P. J.; Lange, U. C.; Surani, M. A.; Affara, N.; Murakami, Y.; Adams, D. J.; Bradley, A. (2006). "Loss of TSLC1 Causes Male Infertility Due to a Defect at the Spermatid Stage of Spermatogenesis". Molecular and Cellular Biology 26 (9): 3595–3609. doi:10.1128/MCB.26.9.3595-3609.2006. PMC 1447413. PMID 16611999.
8. van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism.". Genome Biol 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
9. Yageta, Mika; Kuramochi Masami; Masuda Mari; Fukami Takeshi; Fukuhara Hiroshi; Maruyama Tomoko; Shibuya Masabumi; Murakami Yoshinori (Sep 2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. (United States) 62 (18): 5129–33. ISSN 0008-5472. PMID 12234973.

Further reading

• Watabe K, Ito A, Koma YI, Kitamura Y (2004). "IGSF4: a new intercellular adhesion molecule that is called by three names, TSLC1, SgIGSF and SynCAM, by virtue of its diverse function.". Histol. Histopathol. 18 (4): 1321–9. PMID 12973698.
• Kuramochi M, Fukuhara H, Nobukuni T, et al. (2001). "TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer". Nat. Genet. 27 (4): 427–30. doi:10.1038/86934. PMID 11279526.
• Masuda M, Yageta M, Fukuhara H, et al. (2002). "The tumor suppressor protein TSLC1 is involved in cell-cell adhesion". J. Biol. Chem. 277 (34): 31014–9. doi:10.1074/jbc.M203620200. PMID 12050160.
• Fukuhara H, Kuramochi M, Fukami T, et al. (2003). "Promoter methylation of TSLC1 and tumor suppression by its gene product in human prostate cancer". Jpn. J. Cancer Res. 93 (6): 605–9. doi:10.1111/j.1349-7006.2002.tb01297.x. PMID 12079507.
• Allinen M, Peri L, Kujala S, et al. (2002). "Analysis of 11q21-24 loss of heterozygosity candidate target genes in breast cancer: indications of TSLC1 promoter hypermethylation". Genes Chromosomes Cancer 34 (4): 384–9. doi:10.1002/gcc.10079. PMID 12112527.
• Biederer T, Sara Y, Mozhayeva M, et al. (2002). "SynCAM, a synaptic adhesion molecule that drives synapse assembly". Science 297 (5586): 1525–31. doi:10.1126/science.1072356. PMID 12202822.
• Yageta M, Kuramochi M, Masuda M, et al. (2002). "Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer". Cancer Res. 62 (18): 5129–33. PMID 12234973.
• Jansen M, Fukushima N, Rosty C, et al. (2003). "Aberrant methylation of the 5' CpG island of TSLC1 is common in pancreatic ductal adenocarcinoma and is first manifest in high-grade PanlNs". Cancer Biol. Ther. 1 (3): 293–6. PMID 12432281.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Honda T, Tamura G, Waki T, et al. (2003). "Hypermethylation of the TSLC1 gene promoter in primary gastric cancers and gastric cancer cell lines". Jpn. J. Cancer Res. 93 (8): 857–60. doi:10.1111/j.1349-7006.2002.tb01329.x. PMID 12716461.
• Shingai T, Ikeda W, Kakunaga S, et al. (2003). "Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells". J. Biol. Chem. 278 (37): 35421–7. doi:10.1074/jbc.M305387200. PMID 12826663.
• Ito A, Okada M, Uchino K, et al. (2003). "Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma". Lab. Invest. 83 (8): 1175–83. doi:10.1097/01.LAB.0000081391.28136.80. PMID 12920246.
• Fukami T, Fukuhara H, Kuramochi M, et al. (2003). "Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines". Int. J. Cancer 107 (1): 53–9. doi:10.1002/ijc.11348. PMID 12925956.
• Uchino K, Ito A, Wakayama T, et al. (2003). "Clinical implication and prognostic significance of the tumor suppressor TSLC1 gene detected in adenocarcinoma of the lung". Cancer 98 (5): 1002–7. doi:10.1002/cncr.11599. PMID 12942568.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Fukuhara H, Masuda M, Yageta M, et al. (2003). "Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg". Oncogene 22 (40): 6160–5. doi:10.1038/sj.onc.1206744. PMID 13679854.
• Ito T, Shimada Y, Hashimoto Y, et al. (2003). "Involvement of TSLC1 in progression of esophageal squamous cell carcinoma". Cancer Res. 63 (19): 6320–6. PMID 14559819.
• Mao X, Seidlitz E, Ghosh K, et al. (2004). "The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer". Cancer Res. 63 (22): 7979–85. PMID 14633730.