Chemoproteomics

Chemoproteomics is an approach to discovering mechanisms for regulating biological pathways for the purpose of designing new pharmaceutical therapies. It is a chemical proteomic method for pharmacological discovery research.

Introduction

Chemoproteomics can enable drug discovery.^[1] It is a method for identifying protein targets and potential off-target activity.^[2]

The science can be categorized into three categories: affinity pull-down, Capture Compound Mass Spectrometry and activity-based protein profiling.^[3]

Method

A linker molecule connects a small molecule chemical probe (or library of chemical probes) with an analytically detectable bead or other agent for detection or separation.^[4]

References

↑ Raymond E. Moellering and Benjamin F. Cravatt* (2012). "How chemoproteomics can enable drug discovery and development". Chem Biol. 19 (1): 11–22. doi:10.1016/j.chembiol.2012.01.001.
↑ "Target Profiling of Drugs by Chemical Proteomics". Target Discovery Institute - TDI. Retrieved 4 Jan 2016.
↑ Marjeta Urh (2014). "Chemo Proteomics, a Valuable Tool for Biomarker and Drug Discovery". Molecular Biology. doi:10.4172/2168-9547.1000e117.
↑ Sonja Ghidelli-Disse1, Maria Jose Lafuente-Monasterio, David Waterson, Michael Witty, Yassir Younis, Tanya Paquet, Leslie J Street; et al. (2014). "Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics" (PDF). Malaria Journal. doi:10.1186/1475-2875-13-S1-P38.

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Chemoproteomics

Introduction

Method

See also

References