Chlornaphazine
 | |
| Names | |
|---|---|
| IUPAC name
N,N-Bis(2-chloroethyl)naphthalen-2-amine | |
| Other names
Chlornapazine; 2-Naphthylbis(chloroethyl)amine | |
| Identifiers | |
| 494-03-1 | |
| ChEMBL | ChEMBL2107519 |
| ChemSpider | 9885 |
| Jmol interactive 3D | Image |
| KEGG | C16446  |
| PubChem | 10307 |
| UNII | U46E473275 |
| |
| |
| Properties | |
| C14H15Cl2N | |
| Molar mass | 268.18 g·mol−1 |
| Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
| Infobox references | |
Chlornaphazine, a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease.[1] However, a high incidence of bladder cancers in patients receiving treatment with chlornaphthazine led to use of the drug being discontinued.[2]
The International Agency for Research on Cancer has listed chlornaphazine as a human carcinogen.[3]
References
- ↑ Videbaek, A.; Kaae, S. (1954). "2-Naphthylbis(chloroethyl)amine in the treatment of malignant diseases, particularly Hodgkin's disease". Acta Medica Scandinavica 149 (5): 361–368. doi:10.1111/j.0954-6820.1954.tb11446.x. PMID 13180246.
- ↑ Benedicte Laursen (1970). "Cancer of the Bladder in Patients Treated with Chlornaphazine". Br Med J. 3 (5724): 684–685. doi:10.1136/bmj.3.5724.684. PMC 1701774. PMID 5470116.
- ↑ N,N-Bis(2-Chloroethyl)-2-Naphthylamine (Chlornaphazine), International Agency for Research on Cancer
This article is issued from Wikipedia - version of the Wednesday, August 26, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.