Chondroitin 4-sulfotransferase

chondroitin 4-sulfotransferase
Identifiers
EC number	2.8.2.5
CAS number	83589-04-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a chondroitin 4-sulfotransferase (EC 2.8.2.5) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenosine-5'-phosphosulfate + chondroitin $\rightleftharpoons$ adenosine 3',5'-bisphosphate + chondroitin 4'-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and chondroitin, whereas its two products are adenosine 3',5'-bisphosphate and chondroitin 4'-sulfate.

This enzyme belongs to the family of transferases, to be specific, the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:chondroitin 4'-sulfotransferase. This enzyme is also called chondroitin sulfotransferase. This enzyme participates in 3 metabolic pathways: chondroitin sulfate biosynthesis, sulfur metabolism, and the biosynthesis of glycan structures.

References

• Habuchi O, Miyashita N (1982). "Separation and characterization of chondroitin 6-sulfotransferase and chondroitin 4-sulfotransferase from chick embryo cartilage". Biochim. Biophys. Acta 717 (3): 414–21. doi:10.1016/0304-4165(82)90282-3. PMID 6957247.
• Nakanishi Y, Otsu K, Suzuki S (1983). "Enzymatic transfer of galactosyl phosphate from UDP-galactose to UDP-N-acetylglucosamine". FEBS Lett. 151 (1): 15–8. doi:10.1016/0014-5793(83)80332-9. PMID 6130977.
• Nakanishi Y, Shimizu M, Otsu K, Kato S, Tsuji M, Suzuki S (1981). "A terminal 6-sulfotransferase catalyzing a synthesis of N-acetylgalactosamine 4,6-bissulfate residue at the nonreducing terminal position of chondroitin sulfate". J. Biol. Chem. 256 (11): 5443–9. PMID 6787041.
• Suzuki S and Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. I Transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate to mucopolysaccharides". J. Biol. Chem. 235: 257–266. PMID 13835879.
• Suzuki S and Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. II Mechanism of the reaction studied with oligosaccharides and monosaccharides as acceptors". J. Biol. Chem. 235: 267–273. PMID 13835880.
• Suzuki S and Strominger JL (1960). "Enzymatic sulfation of mucopolysaccharides in hen oviduct. III Mechanism of sulfation of chondroitin and chondroitin sulfate A". J. Biol. Chem. 235: 274–276. PMID 13835881.