LECT1

Leukocyte cell derived chemotaxin 1
Identifiers
Symbols	LECT1 ; BRICD3; CHM-I; CHM1; MYETS1
External IDs	OMIM: 605147 MGI: 1341171 HomoloGene: 5095 GeneCards: LECT1 Gene
Gene ontology Cellular component • proteinaceous extracellular matrix • endomembrane system • integral component of membrane Biological process • skeletal system development • endothelial cell morphogenesis • negative regulation of endothelial cell proliferation • proteoglycan metabolic process • negative regulation of angiogenesis • negative regulation of vascular endothelial growth factor receptor signaling pathway • cartilage development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	11061	16840
Ensembl	ENSG00000136110	ENSMUSG00000022025
UniProt	O75829	Q9Z1F6
RefSeq (mRNA)	NM_001011705	NM_010701
RefSeq (protein)	NP_001011705	NP_034831
Location (UCSC)	Chr 13: 52.7 – 52.74 Mb	Chr 14: 79.64 – 79.66 Mb
PubMed search

Chondromodulin-1 is a protein that in humans is encoded by the LECT1 gene.^[1][2][3]

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein, although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage, and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may also be involved in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.^[3]

References

1. Shukunami C, Hiraki Y (Oct 1998). "Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro". Biochem Biophys Res Commun 249 (3): 885–90. doi:10.1006/bbrc.1998.9233. PMID 9731231.
2. Hiraki Y, Mitsui K, Endo N, Takahashi K, Hayami T, Inoue H, Shukunami C, Tokunaga K, Kono T, Yamada M, Takahashi HE, Kondo J (May 1999). "Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells". Eur J Biochem 260 (3): 869–78. doi:10.1046/j.1432-1327.1999.00227.x. PMID 10103018.
3. "Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1".

Further reading

• Hiraki Y, Shukunami C (2000). "Chondromodulin-I as a novel cartilage-specific growth-modulating factor.". Pediatr. Nephrol. 14 (7): 602–5. doi:10.1007/s004670000339. PMID 10912526.
• Hayami T, Shukunami C, Mitsui K, et al. (2000). "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo.". FEBS Lett. 458 (3): 436–40. doi:10.1016/S0014-5793(99)01201-6. PMID 10570955.
• Yanagihara I, Yamagata M, Sakai N, et al. (2000). "Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells.". J. Bone Miner. Res. 15 (3): 421–9. doi:10.1359/jbmr.2000.15.3.421. PMID 10750556.
• Azizan A, Holaday N, Neame PJ (2001). "Post-translational processing of bovine chondromodulin-I.". J. Biol. Chem. 276 (26): 23632–8. doi:10.1074/jbc.M009967200. PMID 11323410.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Aoyama T, Okamoto T, Nagayama S, et al. (2004). "Expression of the chondromodulin-I gene in chondrosarcomas.". Cancer Lett. 204 (1): 61–8. doi:10.1016/j.canlet.2003.09.015. PMID 14744535.
• Aoyama T, Okamoto T, Nagayama S, et al. (2004). "Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3.". J. Biol. Chem. 279 (27): 28789–97. doi:10.1074/jbc.M401273200. PMID 15107420.
• Yoshioka M, Yuasa S, Matsumura K, et al. (2006). "Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.". Nat. Med. 12 (10): 1151–9. doi:10.1038/nm1476. PMID 16980969.