Cinnamoyl-CoA reductase

cinnamoyl-CoA reductase
Identifiers
EC number	1.2.1.44
CAS number	59929-39-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a cinnamoyl-CoA reductase (EC 1.2.1.44) is an enzyme that catalyzes the chemical reaction

cinnamaldehyde + CoA + NADP⁺ $\rightleftharpoons$ cinnamoyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are cinnamaldehyde, CoA, and NADP⁺, whereas its 3 products are cinnamoyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating). Other names in common use include feruloyl-CoA reductase, cinnamoyl-coenzyme A reductase, ferulyl-CoA reductase, feruloyl coenzyme A reductase, p-hydroxycinnamoyl coenzyme A reductase, and cinnamoyl-CoA:NADPH reductase. This enzyme participates in phenylpropanoid biosynthesis.

References

• Gross GG, Kreiten W (1975). "Reduction of coenzyme A thioesters of cinnamic acids with an enzyme preparation from lignifying tissue of Forsythia". FEBS Lett. 54 (2): 259–62. doi:10.1016/0014-5793(75)80087-1. PMID 236926.
• Sarni F, Grand C, Boudet AM (1984). "Purification and properties of cinnamoyl-CoA reductase and cinnamyl alcohol dehydrogenase from poplar stems (Populus X euramericana)". Eur. J. Biochem. 139 (2): 259–65. doi:10.1111/j.1432-1033.1984.tb08002.x. PMID 6365550.
• Wengenmayer H, Ebel J, Grisebach H (1976). "Enzymic synthesis of lignin precursors. Purification and properties of a cinnamoyl-CoA: NADPH reductase from cell suspension cultures of soybean (Glycinemax)". Eur. J. Biochem. 65 (2): 529–36. doi:10.1111/j.1432-1033.1976.tb10370.x. PMID 7454.