Cobalt-precorrin 5A hydrolase

Cobalt-precorrin 5A hydrolase (EC 3.7.1.12, CbiG (gene)) is an enzyme with systematic name cobalt-precorrin 5A acylhydrolase.^[1] This enzyme catalyses the following chemical reaction

cobalt-precorrin-5A + H₂O

\rightleftharpoons

cobalt-precorrin-5B + acetaldehyde + 2 H⁺

This enzyme hydrolyses the ring A acetate delta-lactone of cobalt-precorrin-5A.

References

↑ Kajiwara, Y., Santander, P.J., Roessner, C.A., Perez, L.M. and Scott, A.I. (2006). "Genetically engineered synthesis and structural characterization of cobalt-precorrin 5A and -5B, two new intermediates on the anaerobic pathway to vitamin B₁₂: definition of the roles of the CbiF and CbiG enzymes". J. Am. Chem. Soc. 128 (30): 9971–9978. doi:10.1021/ja062940a. PMID 16866557.

External links

Cobalt-precorrin 5A hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)

Hydrolases: carbon-carbon (EC 3.7)

3.7.1	Fumarylacetoacetate hydrolase Kynureninase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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