Collagen-induced arthritis

Collagen-induced arthritis (CIA) is a condition induced in mice (or rats) to study rheumatoid arthritis.[1]

CIA is induced in mice by injecting them with an emulsion of complete Freund's adjuvant and type II collagen.[2]

In rats only one injection is needed, mice are normally injected twice.[3]

References

  1. ↑ Collagen-induced arthritis as a model for rheumatoid arthritis.
  2. ↑ Collagen-induced arthritis.
  3. ↑ Arthritis in mice induced by a single immunisation with collagen
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