Enadenotucirev

Enadenotucirev is an investigational oncolytic virus that is entering clinical trials for various cancers.[1]

It is an oncolytic A11/Ad3 Chimeric Group B Adenovirus, previously described as oncolytic vaccine ColoAd1.[2]

It is intended to be modified with additional genes to treat different conditions.[1]

In Jan 2015 the European Medicines Agency's (EMA) Committee for Orphan Medical Products (COMP) gave a positive review of enadenotucirev to treat platinum-resistant ovarian cancer.[3]

Clinical trials

As of December 2015 Two phase 1 trials have been registered:[4] EVOLVE[5] and OCTAVE (in ovarian cancer).[6]

In 2014, positive results from EVOLVE were reported.[2]

OCTAVE started phase 1b in March 2016[7] and is due to complete around March 2017.[6]

The Study of Pembrolizumab In Combination with Enadenotucirev (SPICE) study (not yet on clinicaltrials.gov) will assess if enadenotucirev can reverse resistance to checkpoint inhibitors for various tumour types, including metastatic colorectal cancer.[1]

See also

References

This article is issued from Wikipedia - version of the Thursday, March 10, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.