CNTN1

Contactin 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CNTN1 ; F3; GP135; MYPCN
External IDs OMIM: 600016 MGI: 105980 HomoloGene: 7274 GeneCards: CNTN1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 1272 12805
Ensembl ENSG00000018236 ENSMUSG00000055022
UniProt Q12860 P12960
RefSeq (mRNA) NM_001256063 NM_001159647
RefSeq (protein) NP_001242992 NP_001153119
Location (UCSC) Chr 12:
40.69 – 41.07 Mb		 Chr 15:
92.05 – 92.34 Mb
PubMed search

Contactin 1, also known as CNTN1, is a protein which in humans is encoded by the CNTN1 gene.[1][2]

Function

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.[2]

Interactions

CNTN1 has been shown to interact with PTPRB.[3][4]

References

  1. ↑ Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12". Genomics 21 (3): 571–82. doi:10.1006/geno.1994.1316. PMID 7959734.
  2. 1 2 "Entrez Gene: CNTN1 contactin 1".
  3. ↑ Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". The Journal of Cell Biology 136 (4): 907–18. doi:10.1083/jcb.136.4.907. PMC 2132488. PMID 9049255.
  4. ↑ Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J (Jul 1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin". Cell 82 (2): 251–60. doi:10.1016/0092-8674(95)90312-7. PMID 7628014.

Further reading

  • Walsh FS, Doherty P (Nov 1991). "Glycosylphosphatidylinositol anchored recognition molecules that function in axonal fasciculation, growth and guidance in the nervous system". Cell Biology International Reports 15 (11): 1151–66. doi:10.1016/0309-1651(91)90061-M. PMID 1838307. 
  • Peles E, Schlessinger J, Grumet M (Apr 1998). "Multi-ligand interactions with receptor-like protein tyrosine phosphatase beta: implications for intercellular signaling". Trends in Biochemical Sciences 23 (4): 121–4. doi:10.1016/S0968-0004(98)01195-5. PMID 9584610. 
  • Olive S, Dubois C, Schachner M, Rougon G (Nov 1995). "The F3 neuronal glycosylphosphatidylinositol-linked molecule is localized to glycolipid-enriched membrane subdomains and interacts with L1 and fyn kinase in cerebellum". Journal of Neurochemistry 65 (5): 2307–17. doi:10.1046/j.1471-4159.1995.65052307.x. PMID 7595520. 
  • Peles E, Nativ M, Campbell PL, Sakurai T, Martinez R, Lev S, Clary DO, Schilling J, Barnea G, Plowman GD, Grumet M, Schlessinger J (Jul 1995). "The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin". Cell 82 (2): 251–60. doi:10.1016/0092-8674(95)90312-7. PMID 7628014. 
  • Berglund EO, Ranscht B (Jun 1994). "Molecular cloning and in situ localization of the human contactin gene (CNTN1) on chromosome 12q11-q12". Genomics 21 (3): 571–82. doi:10.1006/geno.1994.1316. PMID 7959734. 
  • Reid RA, Bronson DD, Young KM, Hemperly JJ (Jan 1994). "Identification and characterization of the human cell adhesion molecule contactin". Brain Research. Molecular Brain Research 21 (1-2): 1–8. doi:10.1016/0169-328X(94)90372-7. PMID 8164510. 
  • Yoshihara Y, Kawasaki M, Tamada A, Nagata S, Kagamiyama H, Mori K (Sep 1995). "Overlapping and differential expression of BIG-2, BIG-1, TAG-1, and F3: four members of an axon-associated cell adhesion molecule subgroup of the immunoglobulin superfamily". Journal of Neurobiology 28 (1): 51–69. doi:10.1002/neu.480280106. PMID 8586965. 
  • Sakurai T, Lustig M, Nativ M, Hemperly JJ, Schlessinger J, Peles E, Grumet M (Feb 1997). "Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta". The Journal of Cell Biology 136 (4): 907–18. doi:10.1083/jcb.136.4.907. PMC 2132488. PMID 9049255. 
  • Xiao ZC, Taylor J, Montag D, Rougon G, Schachner M (Apr 1996). "Distinct effects of recombinant tenascin-R domains in neuronal cell functions and identification of the domain interacting with the neuronal recognition molecule F3/11". The European Journal of Neuroscience 8 (4): 766–82. doi:10.1111/j.1460-9568.1996.tb01262.x. PMID 9081628. 
  • Xiao ZC, Hillenbrand R, Schachner M, Thermes S, Rougon G, Gomez S (Sep 1997). "Signaling events following the interaction of the neuronal adhesion molecule F3 with the N-terminal domain of tenascin-R". Journal of Neuroscience Research 49 (6): 698–709. doi:10.1002/(SICI)1097-4547(19970915)49:6<698::AID-JNR4>3.0.CO;2-2. PMID 9335257. 
  • Pierre K, Rougon G, Allard M, Bonhomme R, Gennarini G, Poulain DA, Theodosis DT (Jul 1998). "Regulated expression of the cell adhesion glycoprotein F3 in adult hypothalamic magnocellular neurons". The Journal of Neuroscience 18 (14): 5333–43. PMID 9651216. 
  • Revest JM, Faivre-Sarrailh C, Maeda N, Noda M, Schachner M, Rougon G (Apr 1999). "The interaction between F3 immunoglobulin domains and protein tyrosine phosphatases zeta/beta triggers bidirectional signalling between neurons and glial cells". The European Journal of Neuroscience 11 (4): 1134–47. doi:10.1046/j.1460-9568.1999.00521.x. PMID 10103110. 
  • Berglund EO, Murai KK, Fredette B, Sekerková G, Marturano B, Weber L, Mugnaini E, Ranscht B (Nov 1999). "Ataxia and abnormal cerebellar microorganization in mice with ablated contactin gene expression". Neuron 24 (3): 739–50. doi:10.1016/S0896-6273(00)81126-5. PMID 10595523. 
  • Pierre K, Dupouy B, Allard M, Poulain DA, Theodosis DT (Aug 2001). "Mobilization of the cell adhesion glycoprotein F3/contactin to axonal surfaces is activity dependent". The European Journal of Neuroscience 14 (4): 645–56. doi:10.1046/j.0953-816x.2001.01682.x. PMID 11556889. 
  • Kazarinova-Noyes K, Malhotra JD, McEwen DP, Mattei LN, Berglund EO, Ranscht B, Levinson SR, Schachner M, Shrager P, Isom LL, Xiao ZC (Oct 2001). "Contactin associates with Na+ channels and increases their functional expression". The Journal of Neuroscience 21 (19): 7517–25. PMID 11567041. 
  • Pavlou O, Theodorakis K, Falk J, Kutsche M, Schachner M, Faivre-Sarrailh C, Karagogeos D (Jul 2002). "Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members". Molecular and Cellular Neurosciences 20 (3): 367–81. doi:10.1006/mcne.2002.1105. PMID 12139915. 
  • Garwood J, Heck N, Reichardt F, Faissner A (Jun 2003). "Phosphacan short isoform, a novel non-proteoglycan variant of phosphacan/receptor protein tyrosine phosphatase-beta, interacts with neuronal receptors and promotes neurite outgrowth". The Journal of Biological Chemistry 278 (26): 24164–73. doi:10.1074/jbc.M211721200. PMID 12700241. 
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