Cottonmouth

Cottonmouth may refer to:

• Agkistrodon piscivorus, a.k.a. the water moccasin, a venomous and semiaquatic pit viper found in the US
• Agkistrodon contortrix mokasen, a.k.a. the northern copperhead, a venomous pit viper found in the US

Entertainment:

• Cottonmouth, the codename of O-Ren Ishii, Lucy Liu's character in the movie Kill Bill
• Cottonmouth (comics), a supervillain in the fictional Marvel Comics universe
• "Cottonmouth", a song from Australian music artist Sam Sparro, off his eponymous 2008 debut album.
• "Cottonmouth", a song by the Melvins
• "Cottonmouth", a song by Todd Bowie from his 2005 Lucky Space People album
• "Cottonmouth", a song by Emanuel (band) from their 2007 album Black Earth Tiger
• "Cottonmouth", a fictional city and the setting for Rockstar's Manhunt 2
• "Cottonmouth", a character in the 1978 movie Convoy
• "Cotton Mouth", a song by The Doobie Brothers from their 1972 album Toulouse Street
• "Cottonmouth", a song by In Hearts Wake from their 2015 album Skydancer

Other:

• Xerostomia, dryness of the mouth; a medical condition commonly known as "cotton mouth".