Creola bodies

Creola bodies are a histopathologic finding indicative of asthma. Found in a patient's sputum, they are ciliated columnar cells sloughed from the bronchial mucosa of a patient with asthma. Other common findings in the sputum of asthma patients include Charcot-Leyden crystals, Curschmann's Spirals, and eosinophils (and excessive amounts of sputum).

In a study by Yoshihara et al.[1] 60% of pediatric asthmatic patients demonstrating acute symptoms were found to have creola bodies in their sputum. These patients had increased levels of neutrophil-mediated cytokine activity concluding that "epithelial damage is associated with a locally enhanced chemotactic signal for and activity of neutrophils, but not eosinophils, during acute exacerbations of paediatric asthma."

References

  1. Yoshihara, S., et al. "Association of epithelial damage and signs of neutrophil mobilization in the airways during acute exacerbations of paediatric asthma". Clin Exp Immunol. 2006 May; 144(2): 212–216.
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