Cyclic pyranopterin monophosphate

Cyclic pyranopterin monophosphate
Names

Other names cPMP; Precursor Z
Identifiers
CAS Number	150829-29-1^Y
ChemSpider	17221217
Jmol interactive 3D	Image
PubChem	16061579
InChI InChI=1S/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1 Key: CZAKJJUNKNPTTO-AJFJRRQVSA-N InChI=1/C10H14N5O8P/c11-9-14-6-3(7(16)15-9)12-4-8(13-6)22-2-1-21-24(19,20)23-5(2)10(4,17)18/h2,4-5,8,12,17-18H,1H2,(H,19,20)(H4,11,13,14,15,16)/t2-,4-,5+,8-/m1/s1 Key: CZAKJJUNKNPTTO-AJFJRRQVBG
SMILES C1[C@@H]2[C@@H](C([C@H]3[C@@H](O2)Nc4c(c(=O)[nH]c(n4)N)N3)(O)O)OP(=O)(O1)O
Properties
Chemical formula	C₁₀H₁₄N₅O₈P
Molar mass	363.22 g·mol⁻¹
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

Cyclic pyranopterin monophosphate (cPMP) is an experimental treatment for molybdenum cofactor deficiency type A, which was developed by José Santamaría-Araujo and Guenter Schwarz at the German universities TU Braunschweig and the University of Cologne.^[1]^[2]

cPMP is a precursor to molybdenum cofactor, which is required for the enzyme activity of sulfite oxidase, xanthine dehydrogenase/oxidase and aldehyde oxidase.^[3]

References

↑ Günter Schwarz, José Angel Santamaria-Araujo, Stefan Wolf, Heon-Jin Lee, Ibrahim M. Adham, Hermann-Josef Gröne, Herbert Schwegler, Jörn Oliver Sass, Tanja Otte, Petra Hänzelmann, Ralf R. Mendel, Wolfgang Engel and Jochen Reiss (2004). "Rescue of lethal molybdenum cofactor deficiency by a biosynthetic precursor from Escherichia coli". Human Molecular Genetics 13 (12): 1249–1255. doi:10.1093/hmg/ddh136. PMID 15115759.
↑ Doctors risk untried drug to stop baby’s brain dissolving, TimesOnline, November 5, 2009
↑ José Angel Santamaria-Araujo, Berthold Fischer, Tanja Otte, Manfred Nimtz, Ralf R. Mendel, Victor Wray and Günter Schwarz (2004). "The Tetrahydropyranopterin Structure of the Sulfur-free and Metal-free Molybdenum Cofactor Precursor". The Journal of Biological Chemistry 279 (16): 15994–15999. doi:10.1074/jbc.M311815200. PMID 14761975.

External links

Guenter Schwarz Laboratory, Institute for Biochemistry - University of Cologne (English, German)

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