Cytoscape

Cytoscape

Cytoscape home page
Original author(s) Institute of Systems Biology
Initial release July 2002
Stable release 3.2.1 / 11 February 2015 (2015-02-11)
Written in Java
Operating system Any (Java-based)
Type Image processing
License LGPL
Website www.cytoscape.org

Cytoscape is an open source bioinformatics software platform for visualizing molecular interaction networks and integrating with gene expression profiles and other state data. Additional features are available as plugins. Plugins are available for network and molecular profiling analyses, new layouts, additional file format support and connection with databases and searching in large networks. Plugins may be developed using the Cytoscape open Java software architecture by anyone and plugin community development is encouraged.[1][2] Cytoscape also has a JavaScript-centric sister project named Cytoscape.js that can be used to analyse and visualise graphs in JavaScript environments, like a browser.

History

Cytoscape was originally created at the Institute of Systems Biology in Seattle in 2002. Now, it is developed by an international consortium of open source developers. Cytoscape was initially made public in July, 2002 (v0.8); the second release (v0.9) was in November, 2002. and v1.0 was released in March 2003. Version 1.1.1 is the last stable release for the 1.0 series. Version 2.0 was initially released in 2004; Cytoscape 2.83, the final 2.xx version, was released in May 2012. Version 3.0 was released Feb 1, 2013, and the latest version, 3.2.1, was released in February 2015.

Development

The Cytoscape core developer team continues to work on this project and released Cytoscape 3.0 in 2013. This represented a major change in the Cytoscape architecture; it is a more modularized, expandable and maintainable version of the software.[3] As of February 2015, work is beginning on version 3.3.

Usage

Yeast Protein–protein/Protein–DNA interaction network visualized by Cytoscape. Node degree is mapped to node size

While Cytoscape is most commonly used for biological research applications, it is agnostic in terms of usage. Cytoscape can be used to visualize and analyze network graphs of any kind involving nodes and edges (e.g., social networks). A key aspect of the software architecture of Cytoscape is the use of plugins for specialized features. Plugins are developed by core developers and the greater user community.

Features

Input

Visualization

Analysis

See also

References

  1. Shannon P, Markiel A, Ozier O; et al. (2003). "Cytoscape: a software environment for integrated models of biomolecular interaction networks". Genome Res. 13 (11): 2498–504. doi:10.1101/gr.1239303. PMC 403769. PMID 14597658.
  2. Bell GW, Lewitter F (2006). "Visualizing networks". Meth. Enzymol. 411: 408–21. doi:10.1016/S0076-6879(06)11022-8. PMID 16939803.
  3. developer's wiki page.

External links

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