D-sedoheptulose 7-phosphate isomerase

D-sedoheptulose 7-phosphate isomerase (EC 5.3.1.28, sedoheptulose-7-phosphate isomerase, phosphoheptose isomerase, gmhA (gene), lpcA (gene)) is an enzyme with systematic name D-glycero-D-manno-heptose 7-phosphate aldose-ketose-isomerase.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

D-sedoheptulose 7-phosphate

\rightleftharpoons

D-glycero-D-manno-heptose 7-phosphate

In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose.

References

↑ Kneidinger, B., Marolda, C., Graninger, M., Zamyatina, A., McArthur, F., Kosma, P., Valvano, M.A. and Messner, P. (2002). "Biosynthesis pathway of ADP-L-glycero-β-D-manno-heptose in Escherichia coli". J. Bacteriol. 184: 363–369. doi:10.1128/jb.184.2.363-369.2002. PMID 11751812.
↑ Kneidinger, B., Graninger, M., Puchberger, M., Kosma, P. and Messner, P. (2001). "Biosynthesis of nucleotide-activated D-glycero-D-manno-heptose". J. Biol. Chem. 276: 20935–20944. doi:10.1074/jbc.m100378200. PMID 11279237.
↑ Valvano, M.A., Messner, P. and Kosma, P. (2002). "Novel pathways for biosynthesis of nucleotide-activated glycero-manno-heptose precursors of bacterial glycoproteins and cell surface polysaccharides". Microbiology 148: 1979–1989. doi:10.1099/00221287-148-7-1979. PMID 12101286.
↑ Kim, M.S. and Shin, D.H. (2009). "A preliminary X-ray study of sedoheptulose-7-phosphate isomerase from Burkholderia pseudomallei". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 65: 1110–1112. doi:10.1107/s174430910903259x. PMID 19923728.
↑ Taylor, P.L., Blakely, K.M., de Leon, G.P., Walker, J.R., McArthur, F., Evdokimova, E., Zhang, K., Valvano, M.A., Wright, G.D. and Junop, M.S. (2008). "Structure and function of sedoheptulose-7-phosphate isomerase, a critical enzyme for lipopolysaccharide biosynthesis and a target for antibiotic adjuvants". J. Biol. Chem. 283: 2835–2845. doi:10.1074/jbc.m706163200. PMID 18056714.

External links

D-sedoheptulose 7-phosphate isomerase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerases: intramolecular oxidoreductases (EC 5.3)

5.3.1: Aldoses/Ketoses	Triosephosphate isomerase Ribose-5-phosphate isomerase Mannose phosphate isomerase Glucose isomerase

5.3.2: Keto/Enol	Phenylpyruvate tautomerase Oxaloacetate tautomerase

5.3.3: C = C	Steroid D-isomerase Isopentenyl-diphosphate delta isomerase Vinylacetyl-CoA D-isomerase Muconolactone D-isomerase Cholestenol Delta-isomerase (EBP) Methylitaconate D-isomerase Aconitate Delta-isomerase Enoyl CoA isomerase Prostaglandin-A1 Delta-isomerase 5-carboxymethyl-2-hydroxymuconate D-isomerase Isopiperitenone D-isomerase L-dopachrome isomerase Polyenoic fatty acid isomerase

5.3.4: S-S	Protein disulfide-isomerase (PDIA3)

5.3.99: other	Prostaglandin D2 synthase/Prostaglandin-D synthase Prostaglandin E synthase Prostacyclin synthase Thromboxane-A synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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