DAB2IP

DAB2 interacting protein
Identifiers
Symbols	DAB2IP ; AF9Q34; AIP-1; AIP1; DIP1/2
External IDs	OMIM: 609205 MGI: 1916851 HomoloGene: 13058 GeneCards: DAB2IP Gene
Gene ontology Molecular function • GTPase activator activity • death receptor binding • protein binding • SH3 domain binding • kinase binding • protein kinase binding • mitogen-activated protein kinase kinase binding • mitogen-activated protein kinase kinase kinase binding • phosphatidylinositol-3-phosphate binding • protein complex binding • signaling adaptor activity • Toll-like receptor 4 binding • phosphatidylinositol 3-kinase regulatory subunit binding • identical protein binding • protein homodimerization activity • vascular endothelial growth factor receptor 2 binding • phosphatidylinositol 3-kinase binding • protein phosphatase 2A binding • phosphatidylinositol-4-phosphate binding • 14-3-3 protein binding Cellular component • cytoplasm • plasma membrane • endocytic vesicle • axon • dendrite • intrinsic component of the cytoplasmic side of the plasma membrane • neuronal cell body membrane • neuronal cell body • cerebellar mossy fiber • climbing fiber • extracellular exosome • parallel fiber • AIP1-IRE1 complex Biological process • negative regulation of transcription from RNA polymerase II promoter • activation of MAPKKK activity • angiogenesis • negative regulation of protein phosphorylation • transformed cell apoptotic process • inflammatory response • activation of signaling protein activity involved in unfolded protein response • cell cycle • I-kappaB phosphorylation • activation of JUN kinase activity • negative regulation of cell proliferation • extrinsic apoptotic signaling pathway via death domain receptors • negative regulation of endothelial cell migration • negative regulation of epithelial cell migration • negative regulation of epithelial to mesenchymal transition • positive regulation of neuron projection development • negative regulation of phosphatidylinositol 3-kinase signaling • negative regulation of angiogenesis • cell motility involved in cerebral cortex radial glia guided migration • layer formation in cerebral cortex • negative regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of NF-kappaB transcription factor activity • negative regulation of toll-like receptor 4 signaling pathway • negative regulation of GTPase activity • tube formation • negative regulation of catenin import into nucleus • cellular response to vascular endothelial growth factor stimulus • vascular endothelial growth factor receptor-2 signaling pathway • reelin-mediated signaling pathway • regulation of growth • negative regulation of epidermal growth factor receptor signaling pathway • positive regulation of apoptotic process • regulation of GTPase activity • regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of I-kappaB kinase/NF-kappaB signaling • regulation of protein complex assembly • negative regulation of MAP kinase activity • positive regulation of MAPK cascade • regulation of protein heterodimerization activity • positive regulation of JUN kinase activity • positive regulation of GTPase activity • negative regulation of phosphatidylinositol 3-kinase activity • cellular protein catabolic process • innate immune response • positive regulation of protein catabolic process • negative regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • positive regulation of JNK cascade • negative regulation of Ras protein signal transduction • negative regulation of fibroblast proliferation • neuron projection morphogenesis • negative regulation of epithelial cell proliferation • intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress • negative regulation of G0 to G1 transition • negative regulation of ERK1 and ERK2 cascade • positive regulation of cell cycle arrest • cellular response to lipopolysaccharide • cellular response to interleukin-1 • cellular response to tumor necrosis factor • cellular response to epidermal growth factor stimulus • negative regulation of protein serine/threonine kinase activity • positive regulation of protein serine/threonine kinase activity • endothelial cell apoptotic process • negative regulation of canonical Wnt signaling pathway • positive regulation of synapse maturation • positive regulation of dendrite development • regulation of p38MAPK cascade • negative regulation of vascular endothelial growth factor signaling pathway • positive regulation of proteasomal protein catabolic process • positive regulation of IRE1-mediated unfolded protein response • negative regulation of cyclin catabolic process • positive regulation of neuron migration • positive regulation of apoptotic signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	153090	69601
Ensembl	ENSG00000136848	ENSMUSG00000026883
UniProt	Q5VWQ8	Q3UHC7
RefSeq (mRNA)	NM_032552	NM_001001602
RefSeq (protein)	NP_115941	NP_001001602
Location (UCSC)	Chr 9: 121.57 – 121.79 Mb	Chr 2: 35.56 – 35.73 Mb
PubMed search

Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene.^[1][2][3]

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]^[3]

Interactions

DAB2IP has been shown to interact with DAB2.^[4]

References

1. Chen H, Pong RC, Wang Z, Hsieh JT (April 2002). "Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization". Genomics 79 (4): 573–81. doi:10.1006/geno.2002.6739. PMID 11944990.
2. Wang Z, Tseng CP, Pong RC, Chen H, McConnell JD, Navone N, Hsieh JT (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem 277 (15): 12622–31. doi:10.1074/jbc.M110568200. PMID 11812785.
3. "Entrez Gene: DAB2IP DAB2 interacting protein".
4. Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone Nora; Hsieh Jer-Tsong (April 2002). "The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. (United States) 277 (15): 12622–31. doi:10.1074/jbc.M110568200. ISSN 0021-9258. PMID 11812785.

Further reading

• Nakajima D, Okazaki N, Yamakawa H; et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Hattori A; et al. (2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi:10.1093/dnares/7.6.347. PMID 11214970.
• Chen H, Toyooka S, Gazdar AF, Hsieh JT (2003). "Epigenetic regulation of a novel tumor suppressor gene (hDAB2IP) in prostate cancer cell lines". J. Biol. Chem. 278 (5): 3121–30. doi:10.1074/jbc.M208230200. PMID 12446720.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Zhang R, He X, Liu W; et al. (2003). "AIP1 mediates TNF-α–induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3". J. Clin. Invest. 111 (12): 1933–43. doi:10.1172/JCI17790. PMC 161425. PMID 12813029.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• von Bergh AR, Wijers PM, Groot AJ; et al. (2004). "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia". Genes Chromosomes Cancer 39 (4): 324–34. doi:10.1002/gcc.20004. PMID 14978793.
• Dote H, Toyooka S, Tsukuda K; et al. (2004). "Aberrant promoter methylation in human DAB2 interactive protein (hDAB2IP) gene in breast cancer". Clin. Cancer Res. 10 (6): 2082–9. doi:10.1158/1078-0432.CCR-03-0236. PMID 15041729.
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Zhang H, Zhang R, Luo Y; et al. (2004). "AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation". J. Biol. Chem. 279 (43): 44955–65. doi:10.1074/jbc.M407617200. PMID 15310755.
• Yano M, Toyooka S, Tsukuda K; et al. (2004). "Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers". Int. J. Cancer 113 (1): 59–66. doi:10.1002/ijc.20531. PMID 15386433.
• Chen H, Tu SW, Hsieh JT (2005). "Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer". J. Biol. Chem. 280 (23): 22437–44. doi:10.1074/jbc.M501379200. PMID 15817459.
• Kunze E, Von Bonin F, Werner C; et al. (2006). "Transitional cell carcinomas and nonurothelial carcinomas of the urinary bladder differ in the promoter methylation status of the caveolin-1, hDAB2IP and p53 genes, but not in the global methylation of Alu elements". Int. J. Mol. Med. 17 (1): 3–13. doi:10.3892/ijmm.17.1.3. PMID 16328005.
• Beausoleil SA, Villén J, Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.