DACH1

Dachshund family transcription factor 1
PDB rendering based on 1l8r.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1L8R​
Identifiers
Symbols	DACH1 ; DACH
External IDs	OMIM: 603803 MGI: 1277991 HomoloGene: 7288 GeneCards: DACH1 Gene
Gene ontology Molecular function • transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • DNA binding • protein binding Cellular component • nucleus • nucleoplasm • transcription factor complex • nucleolus • cytoplasm • intracellular membrane-bounded organelle Biological process • negative regulation of transcription from RNA polymerase II promoter • suckling behavior • respiratory gaseous exchange • cell proliferation • negative regulation of transcription by competitive promoter binding • negative regulation of cell migration • regulation of nuclear cell cycle DNA replication • negative regulation of transcription, DNA-templated • development of primary female sexual characteristics • negative regulation of fibroblast proliferation • RNA polymerase II transcriptional preinitiation complex assembly • negative regulation of cell proliferation involved in contact inhibition • negative regulation of DNA biosynthetic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1602	13134
Ensembl	ENSG00000276644	ENSMUSG00000055639
UniProt	Q9UI36	Q9QYB2
RefSeq (mRNA)	NM_004392	NM_001038610
RefSeq (protein)	NP_004383	NP_001033699
Location (UCSC)	Chr 13: 71.44 – 71.87 Mb	Chr 14: 97.79 – 98.17 Mb
PubMed search

Dachshund homolog 1 (Drosophila), also known as DACH1, is a protein which in humans is encoded by the DACH1 gene.^[1][2][3]

Function

This gene is similar to the D. melanogaster dachshund gene, which encodes a nuclear factor essential for determining cell fates in the eye, leg, and nervous system of the fly. It is a member of the Ski gene family and is thought to be involved in eye development. Four alternatively spliced transcripts encoding different isoforms have been described for this gene.^[3]

Interactions

DACH1 has been shown to interact with UBE2I,^[4][5] Smad4 and NCoR.^[6]

References

1. Hammond KL, Lettice LA, Hill RE, Lee M, Boyle S, Hanson IM (January 1999). "Human (DACH) and mouse (Dach) homologues of Drosophila dachshund map to chromosomes 13q22 and 14E3, respectively". Genomics 55 (2): 252–253. doi:10.1006/geno.1998.5662. PMID 9933575.
2. Kozmik Z, Cvekl A (July 1999). "Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21". Genomics 59 (1): 110–111. doi:10.1006/geno.1999.5797. PMID 10395809.
3. "Entrez Gene: DACH1 dachshund homolog 1 (Drosophila)".
4. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
5. Machon O, Backman M, Julin K, Krauss S (October 2000). "Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac". Mech. Dev. 97 (1–2): 3–12. doi:10.1016/S0925-4773(00)00402-0. PMID 11025202.
6. Wu, Kongming; Yang, Ying; Wang, Chenguang; Davoli, Maria A.; D'Amico, Mark; Li, Anping; Cveklova, Kveta; Kozmik, Zbynek; Lisanti, Michael P. (2003-12-19). "DACH1 inhibits transforming growth factor-beta signaling through binding Smad4". The Journal of Biological Chemistry 278 (51): 51673–51684. doi:10.1074/jbc.M310021200. ISSN 0021-9258. PMID 14525983.

Further reading

• Hammond KL, Hanson IM, Brown AG, Lettice LA, Hill RE (2003). "Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb". Mech. Dev. 74 (1–2): 121–131. doi:10.1016/S0925-4773(98)00071-9. PMID 9651501.
• Hammond KL, Lettice LA, Hill RE, Lee M, Boyle S, Hanson IM (1999). "Human (DACH) and mouse (Dach) homologues of Drosophila dachshund map to chromosomes 13q22 and 14E3, respectively". Genomics 55 (2): 252–253. doi:10.1006/geno.1998.5662. PMID 9933575.
• Kozmik Z, Cvekl A (1999). "Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21". Genomics 59 (1): 110–111. doi:10.1006/geno.1999.5797. PMID 10395809.
• Kozmik Z, Pfeffer P, Kralova J, Paces J, Paces V, Kalousova A, Cvekl A (1999). "Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene". Dev. Genes Evol. 209 (9): 537–545. doi:10.1007/s004270050286. PMID 10502110.
• Machon O, Backman M, Julin K, Krauss S (2001). "Yeast two-hybrid system identifies the ubiquitin-conjugating enzyme mUbc9 as a potential partner of mouse Dac". Mech. Dev. 97 (1–2): 3–12. doi:10.1016/S0925-4773(00)00402-0. PMID 11025202.
• Ayres JA, Shum L, Akarsu AN, Dashner R, Takahashi K, Ikura T, Slavkin HC, Nuckolls GH (2001). "DACH: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homologue". Genomics 77 (1–2): 18–26. doi:10.1006/geno.2001.6618. PMID 11543628.
• Ozaki H, Watanabe Y, Ikeda K, Kawakami K (2002). "Impaired interactions between mouse Eyal harboring mutations found in patients with branchio-oto-renal syndrome and Six, Dach, and G proteins". J. Hum. Genet. 47 (3): 0107–0116. doi:10.1007/s100380200011. PMID 11950062.
• Kim SS, Zhang RG, Braunstein SE, Joachimiak A, Cvekl A, Hegde RS (2003). "Structure of the retinal determination protein Dachshund reveals a DNA binding motif". Structure 10 (6): 787–795. doi:10.1016/S0969-2126(02)00769-4. PMID 12057194.
• Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–6766. doi:10.1128/MCB.22.19.6759-6766.2002. PMC 134036. PMID 12215533.
• Wu K, Yang Y, Wang C, Davoli MA, D'Amico M, Li A, Cveklova K, Kozmik Z, Lisanti MP, Russell RG, Cvekl A, Pestell RG (2004). "DACH1 inhibits transforming growth factor-beta signaling through binding Smad4". J. Biol. Chem. 278 (51): 51673–51684. doi:10.1074/jbc.M310021200. PMID 14525983.
• Nobrega MA, Ovcharenko I, Afzal V, Rubin EM (2003). "Scanning human gene deserts for long-range enhancers". Science 302 (5644): 413–413. doi:10.1126/science.1088328. PMID 14563999.
• Li X, Oghi KA, Zhang J, Krones A, Bush KT, Glass CK, Nigam SK, Aggarwal AK, Maas R, Rose DW, Rosenfeld MG (2003). "Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis". Nature 426 (6964): 247–254. doi:10.1038/nature02083. PMID 14628042.
• Martini SR, Davis RL (2005). "The dachshund gene is required for the proper guidance and branching of mushroom body axons in Drosophila melanogaster". J. Neurobiol. 64 (2): 133–144. doi:10.1002/neu.20130. PMID 15818552.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
• Wu K, Li A, Rao M, Liu M, Dailey V, Yang Y, Di Vizio D, Wang C, Lisanti MP, Sauter G, Russell RG, Cvekl A, Pestell RG (2006). "DACH1 is a cell fate determination factor that inhibits cyclin D1 and breast tumor growth". Mol. Cell. Biol. 26 (19): 7116–7129. doi:10.1128/MCB.00268-06. PMC 1592900. PMID 16980615.