DAOA-AS1
| DAOA antisense RNA 1 | |||||
|---|---|---|---|---|---|
| Identifiers | |||||
| Symbols | DAOA-AS1 ; DAOA-AS; DAOAAS; G30 | ||||
| External IDs | OMIM: 607415 GeneCards: DAOA-AS1 Gene | ||||
| |||||
| Orthologs | |||||
| Species | Human | Mouse | |||
| Entrez | 282706 | n/a | |||
| Ensembl | ENSG00000232307 | n/a | |||
| UniProt | n/a | n/a | |||
| RefSeq (mRNA) | n/a | n/a | |||
| RefSeq (protein) | n/a | n/a | |||
| Location (UCSC) |
Chr 13: 105.46 – 105.51 Mb | n/a | |||
| PubMed search | n/a | ||||
In molecular biology, DAOA-AS1, DAOA antisense RNA 1 (non-protein coding), (formerly known as G30), is a human gene encoding a long non-coding RNA. It was originally identified in a screen for genes associated with schizophrenia.[1] It is also associated with bipolar disorder and other psychiatric phenotypes.[2][3] It may regulate the expression of the DAOA gene.[1]
See also
References
- 1 2 Chumakov I, Blumenfeld M, Guerassimenko O, Cavarec L, Palicio M, Abderrahim H, et al. (Oct 2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia". Proceedings of the National Academy of Sciences of the United States of America 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMC 129739. PMID 12364586.
- ↑ Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (May 2003). "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series". American Journal of Human Genetics 72 (5): 1131–40. doi:10.1086/374822. PMC 1180266. PMID 12647258.
- ↑ Abou Jamra R, Schmael C, Cichon S, Rietschel M, Schumacher J, Nöthen MM (Oct 2006). "The G72/G30 gene locus in psychiatric disorders: a challenge to diagnostic boundaries?". Schizophrenia Bulletin 32 (4): 599–608. doi:10.1093/schbul/sbl028. PMC 2632259. PMID 16914640.
Further reading
- Hattori E, Liu C, Badner JA, Bonner TI, Christian SL, Maheshwari M, Detera-Wadleigh SD, Gibbs RA, Gershon ES (May 2003). "Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series". American Journal of Human Genetics 72 (5): 1131–40. doi:10.1086/374822. PMC 1180266. PMID 12647258.
- Wang X, He G, Gu N, Yang J, Tang J, Chen Q, Liu X, Shen Y, Qian X, Lin W, Duan Y, Feng G, He L (Jul 2004). "Association of G72/G30 with schizophrenia in the Chinese population". Biochemical and Biophysical Research Communications 319 (4): 1281–6. doi:10.1016/j.bbrc.2004.05.119. PMID 15194506.
- Korostishevsky M, Kaganovich M, Cholostoy A, Ashkenazi M, Ratner Y, Dahary D, Bernstein J, Bening-Abu-Shach U, Ben-Asher E, Lancet D, Ritsner M, Navon R (Aug 2004). "Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis". Biological Psychiatry 56 (3): 169–76. doi:10.1016/j.biopsych.2004.04.006. PMID 15271585.
- Schumacher J, Abou Jamra R, Becker T, Klopp N, Franke P, Jacob C, Sand P, Fritze J, Ohlraun S, Schulze TG, Rietschel M, Illig T, Propping P, Cichon S, Deckert J, Nöthen MM (May 2005). "Investigation of the DAOA/G30 locus in panic disorder". Molecular Psychiatry 10 (5): 428–9. doi:10.1038/sj.mp.4001598. PMID 15477870.
- Britten RJ (Nov 2004). "Coding sequences of functioning human genes derived entirely from mobile element sequences". Proceedings of the National Academy of Sciences of the United States of America 101 (48): 16825–30. doi:10.1073/pnas.0406985101. PMC 534736. PMID 15546984.
- Zou F, Li C, Duan S, Zheng Y, Gu N, Feng G, Xing Y, Shi J, He L (Mar 2005). "A family-based study of the association between the G72/G30 genes and schizophrenia in the Chinese population". Schizophrenia Research 73 (2-3): 257–61. doi:10.1016/j.schres.2004.01.015. PMID 15653269.
- Mulle JG, McDonough JA, Chowdari KV, Nimgaonkar V, Chakravarti A (May 2005). "Evidence for linkage to chromosome 13q32 in an independent sample of schizophrenia families". Molecular Psychiatry 10 (5): 429–31. doi:10.1038/sj.mp.4001639. PMID 15738936.
- Ma J, Qin W, Wang XY, Guo TW, Bian L, Duan SW, Li XW, Zou FG, Fang YR, Fang JX, Feng GY, Gu NF, St Clair D, He L (May 2006). "Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations". Molecular Psychiatry 11 (5): 479–87. doi:10.1038/sj.mp.4001788. PMID 16402132.
- Hong CJ, Hou SJ, Yen FC, Liou YJ, Tsai SJ (Jul 2006). "Family-based association study between G72/G30 genetic polymorphism and schizophrenia". NeuroReport 17 (10): 1067–9. doi:10.1097/01.wnr.0000224763.61959.26. PMID 16791105.
- Li D, He L (Feb 2007). "G72/G30 genes and schizophrenia: a systematic meta-analysis of association studies". Genetics 175 (2): 917–22. doi:10.1534/genetics.106.061796. PMC 1800627. PMID 17179078.
- Yue W, Liu Z, Kang G, Yan J, Tang F, Ruan Y, Zhang J, Zhang D (Dec 2006). "Association of G72/G30 polymorphisms with early-onset and male schizophrenia". NeuroReport 17 (18): 1899–902. doi:10.1097/WNR.0b013e3280102ed4. PMID 17179866.
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