DAP (gene)

Death-associated protein
Identifiers
Symbols	DAP ; MGC99796
External IDs	OMIM: 600954 MGI: 1918190 HomoloGene: 3235 GeneCards: DAP Gene
Gene ontology Molecular function • death domain binding Biological process • autophagy • apoptotic process • activation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of autophagy • negative regulation of NF-kappaB transcription factor activity • cellular response to amino acid starvation • negative regulation of transcription, DNA-templated • apoptotic signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1611	223453
Ensembl	ENSG00000112977	ENSMUSG00000039168
UniProt	P51397	Q91XC8
RefSeq (mRNA)	NM_001291963	NM_146057
RefSeq (protein)	NP_001278892	NP_666169
Location (UCSC)	Chr 5: 10.68 – 10.76 Mb	Chr 15: 31.22 – 31.27 Mb
PubMed search

Death-associated protein 1 is a protein that in humans is encoded by the DAP gene.^[1][2][3]

DAP gene encodes a basic, proline-rich, 15-kD protein. Death-associated protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma.^[3]

References

1. Feinstein E, Druck T, Kastury K, Berissi H, Goodart SA, Overhauser J, Kimchi A, Huebner K (Feb 1996). "Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively". Genomics 29 (1): 305–7. doi:10.1006/geno.1995.1255. PMID 8530096.
2. Deiss LP, Feinstein E, Berissi H, Cohen O, Kimchi A (Feb 1995). "Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death". Genes Dev 9 (1): 15–30. doi:10.1101/gad.9.1.15. PMID 7828849.
3. "Entrez Gene: DAP death-associated protein".

Further reading

• Levy-Strumpf N, Kimchi A (1999). "Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions". Oncogene 17 (25): 3331–40. doi:10.1038/sj.onc.1202588. PMID 9916995.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Zougman A, Wiśniewski JR (2006). "Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins". J. Proteome Res. 5 (4): 925–34. doi:10.1021/pr050415p. PMID 16602700.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.