DATP(dGTP)—DNA purinetransferase

DATP(dGTP)---DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.^[1]^[2] This enzyme catalyses the following chemical reaction

(1) dATP + depurinated DNA

\rightleftharpoons

deoxyribose triphosphate + DNA

(2) dGTP + depurinated DNA

\rightleftharpoons

deoxyribose triphosphate + DNA

The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.

References

↑ Deutsch, W.A. and Linn, S. (1979). "DNA binding activity from cultured human fibroblasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proc. Natl. Acad. Sci. USA 76: 141–144. doi:10.1073/pnas.76.1.141. PMID 218192.
↑ Livneh, Z., Elad, D. and Sperling, J. (1979). "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proc. Natl. Acad. Sci. USA 76: 1089–1093. doi:10.1073/pnas.76.3.1089. PMID 375225.

External links

DATP(dGTP)---DNA purinetransferase at the US National Library of Medicine Medical Subject Headings (MeSH)

Transferase: nitrogenous groups (EC 2.6)

2.6.1: Transaminases	Aspartate transaminase GOT1 GOT2 Alanine transaminase GABA transaminase Tyrosine aminotransferase Ornithine aminotransferase Branched chain aminotransferase Alanine—glyoxylate transaminase AGXT

2.6.3: Oximinotransferases	Oximinotransferase

2.6.99: Other	Pyridoxine 5'-phosphate synthase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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