DBC1

Bone morphogenetic protein/retinoic acid inducible neural-specific 1
Identifiers
Symbols	BRINP1 ; DBC1; DBCCR1; FAM5A
External IDs	OMIM: 602865 MGI: 1928478 HomoloGene: 8754 GeneCards: BRINP1 Gene
Gene ontology Molecular function • protein binding Cellular component • cytoplasm Biological process • cell cycle arrest • cell death • positive regulation of neuron differentiation • negative regulation of cell cycle • negative regulation of mitotic cell cycle • cellular response to retinoic acid Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1620	56710
Ensembl	ENSG00000078725	ENSMUSG00000028351
UniProt	O60477	Q920P3
RefSeq (mRNA)	NM_014618	NM_019967
RefSeq (protein)	NP_055433	NP_064351
Location (UCSC)	Chr 9: 119.15 – 119.37 Mb	Chr 4: 68.76 – 68.95 Mb
PubMed search

Deleted in bladder cancer protein 1 is a protein that in humans is encoded by the DBC1 gene.^{[1][2][3][4][5]}

This gene is located within chromosome 9 (9q32-33), a chromosomal region that frequently shows loss of heterozygosity in transitional cell carcinoma of the bladder. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers.^[3]

The functions of this gene are unknown, and it has not yet been placed in a protein family or functional pathway. Nonetheless, it is suspected to act as a tumor suppressor gene.

References

1. Habuchi T, Yoshida O, Knowles MA (Jul 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum Mol Genet 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
2. Nishiyama H, Hornigold N, Davies AM, Knowles MA (Nov 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.
3. "Entrez Gene: DBC1 deleted in bladder cancer 1".
4. Habuchi T, Yoshida O, Knowles MA (June 1997). "A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC". Hum. Mol. Genet. 6 (6): 913–9. doi:10.1093/hmg/6.6.913. PMID 9175739.
5. Nishiyama H, Hornigold N, Davies AM, Knowles MA (August 1999). "A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33". Genomics 59 (3): 335–8. doi:10.1006/geno.1999.5891. PMID 10444335.

Further reading

• Auffray C, Behar G, Bois F; et al. (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". C. R. Acad. Sci. III, Sci. Vie 318 (2): 263–72. PMID 7757816.
• Habuchi T, Luscombe M, Elder PA, Knowles MA (1998). "Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33.". Genomics 48 (3): 277–88. doi:10.1006/geno.1997.5165. PMID 9545632.
• Nishiyama H, Takahashi T, Kakehi Y; et al. (2000). "Homozygous deletion at the 9q32-33 candidate tumor suppressor locus in primary human bladder cancer.". Genes Chromosomes Cancer 26 (2): 171–5. doi:10.1002/(SICI)1098-2264(199910)26:2<171::AID-GCC10>3.0.CO;2-B. PMID 10469456.
• Nishiyama H, Gill JH, Pitt E; et al. (2001). "Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1.". Oncogene 20 (23): 2956–64. doi:10.1038/sj.onc.1204432. PMID 11420708.
• Wright KO, Messing EM, Reeder JE (2002). "Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors.". J. Urol. 168 (6): 2645–9. doi:10.1097/01.ju.0000037848.19383.88. PMID 12442002.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Wright KO, Messing EM, Reeder JE (2004). "DBCCR1 mediates death in cultured bladder tumor cells.". Oncogene 23 (1): 82–90. doi:10.1038/sj.onc.1206642. PMID 14712213.
• Humphray SJ, Oliver K, Hunt AR; et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Beetz C, Brodoehl S, Patt S; et al. (2005). "Low expression but infrequent genomic loss of the putative tumour suppressor DBCCR1 in astrocytoma.". Oncol. Rep. 13 (2): 335–40. doi:10.3892/or.13.2.335. PMID 15643521.
• Izumi H, Inoue J, Yokoi S; et al. (2005). "Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers.". Hum. Mol. Genet. 14 (8): 997–1007. doi:10.1093/hmg/ddi092. PMID 15746151.
• Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Louhelainen JP, Hurst CD, Pitt E; et al. (2006). "DBC1 re-expression alters the expression of multiple components of the plasminogen pathway.". Oncogene 25 (16): 2409–19. doi:10.1038/sj.onc.1209228. PMID 16369496.