DCTN4

Dynactin 4 (p62)
Identifiers
Symbols	DCTN4 ; DYN4; P62
External IDs	OMIM: 614758 HomoloGene: 9430 GeneCards: DCTN4 Gene
Gene ontology Molecular function • protein binding • protein N-terminus binding Cellular component • nucleus • cytoplasm • centrosome • cytosol • cytoplasmic dynein complex • dynactin complex Biological process • nuclear migration • antigen processing and presentation of exogenous peptide antigen via MHC class II Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51164	67665
Ensembl	ENSG00000132912	ENSMUSG00000024603
UniProt	Q9UJW0	Q8CBY8
RefSeq (mRNA)	NM_001135643	NM_026302
RefSeq (protein)	NP_001129115	NP_080578
Location (UCSC)	Chr 5: 150.71 – 150.76 Mb	Chr 18: 60.53 – 60.56 Mb
PubMed search

Dynactin subunit 4 is a protein that in humans is encoded by the DCTN4 gene.^[1]

References

1. "Entrez Gene: Dynactin 4 (p62)".

Further reading

• Karki, S.; Tokito, M. K.; Holzbaur, E. L. (2000). "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1". The Journal of Biological Chemistry 275 (7): 4834–4839. doi:10.1074/jbc.275.7.4834. PMID 10671518.
• Emond, M. J.; Louie, T.; Emerson, J.; Zhao, W.; Mathias, R. A.; Knowles, M. R.; Wright, F. A.; Rieder, M. J.; Tabor, H. K.; Nickerson, D. A.; Barnes, K. C.; Gibson, R. L.; Bamshad, M. J. (2012). "Exome sequencing of extreme phenotypes identifies DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis". Nature Genetics 44 (8): 886–889. doi:10.1038/ng.2344. PMC 3702264. PMID 22772370.
• Ayalon, G.; Davis, J. Q.; Scotland, P. B.; Bennett, V. (2008). "An Ankyrin-Based Mechanism for Functional Organization of Dystrophin and Dystroglycan". Cell 135 (7): 1189–1200. doi:10.1016/j.cell.2008.10.018. PMID 19109891.
• Bingham, J. B.; Schroer, T. A. (1999). "Self-regulated polymerization of the actin-related protein Arp1". Current Biology 9 (4): 223–226. doi:10.1016/S0960-9822(99)80095-5. PMID 10074429.
• Lim, C. M.; Cater, M. A.; Mercer, J. F.; La Fontaine, S. (2006). "Copper-dependent Interaction of Dynactin Subunit p62 with the N Terminus of ATP7B but Not ATP7A". Journal of Biological Chemistry 281 (20): 14006–14014. doi:10.1074/jbc.M512745200. PMID 16554302.
• Boultwood, J.; Fidler, C.; Strickson, A. J.; Watkins, F.; Kostrzewa, M.; Jaju, R. J.; Müller, U.; Wainscoat, J. S. (2000). "Transcription Mapping of the 5q− Syndrome Critical Region: Cloning of Two Novel Genes and Sequencing, Expression, and Mapping of a Further Six Novel cDNAs". Genomics 66 (1): 26–34. doi:10.1006/geno.2000.6193. PMID 10843801.