DDT-dehydrochlorinase

DDT-dehydrochlorinase
Identifiers
EC number	4.5.1.1
CAS number	9031-20-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a DDT-dehydrochlorinase (EC 4.5.1.1) is an enzyme that catalyzes the chemical reaction

1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane $\rightleftharpoons$ 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride

Hence, this enzyme has one substrate, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane, and two products, 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene and chloride.

This enzyme belongs to the family of lyases, specifically the class of carbon-halide lyases. The systematic name of this enzyme class is 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]. Other names in common use include DDT-ase, 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase, and DDTase. This enzyme participates in 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) and [[]].

References

• LIPKE H, KEARNS CW (1959). "DDT dehydrochlorinase. I. Isolation, chemical properties, and spectrophotometric assay". J. Biol. Chem. 234 (8): 2123–8. PMID 13673024.
• LIPKE H, KEARNS CW (1959). "DDT dehydrochlorinase. II. Substrate and cofactor specificity". J. Biol. Chem. 234 (8): 2129–32. PMID 13673025.
• Moorefield HH (1956). "Purification of DDT-dehydrochlorinase from resistant houseflies". Contr. Boyce Thompson Inst. 18: 303–310.