DDX41

DEAD (Asp-Glu-Ala-Asp) box polypeptide 41
PDB rendering based on 2p6n.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2P6N​
Identifiers
Symbols	DDX41 ; ABS
External IDs	OMIM: 608170 MGI: 1920185 HomoloGene: 9431 GeneCards: DDX41 Gene
EC number	3.6.4.13
Gene ontology Molecular function • DNA binding • ATP-dependent RNA helicase activity • protein binding • ATP binding • zinc ion binding • poly(A) RNA binding Cellular component • endoplasmic reticulum • cytosol • membrane • catalytic step 2 spliceosome Biological process • mRNA splicing, via spliceosome • RNA processing • apoptotic process • multicellular organismal development • RNA secondary structure unwinding • regulation of type I interferon production • positive regulation of type I interferon production • cellular response to interferon-beta • innate immune response • positive regulation of transcription from RNA polymerase II promoter • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	51428	72935
Ensembl	ENSG00000183258	ENSMUSG00000021494
UniProt	Q9UJV9	Q91VN6
RefSeq (mRNA)	NM_016222	NM_134059
RefSeq (protein)	NP_057306	NP_598820
Location (UCSC)	Chr 5: 177.51 – 177.52 Mb	Chr 13: 55.53 – 55.54 Mb
PubMed search

Probable ATP-dependent RNA helicase DDX41 is an enzyme that in humans is encoded by the DDX41 gene.^[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of the DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. The function of this member has not been determined. Based on studies in Drosophila, the abstrakt gene is widely required during post-transcriptional gene expression.^[2]

References

1. Irion U, Leptin M (Feb 2000). "Developmental and cell biological functions of the Drosophila DEAD-box protein abstrakt". Curr Biol 9 (23): 1373–81. doi:10.1016/S0960-9822(00)80082-2. PMID 10607561.
2. "Entrez Gene: DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Jurica MS, Licklider LJ, Gygi SR; et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Abdul-Ghani M, Hartman KL, Ngsee JK (2005). "Abstrakt Interacts With and Regulates the Expression of Sorting Nexin-2". J. Cell. Physiol. 204 (1): 210–8. doi:10.1002/jcp.20285. PMC 2963638. PMID 15690390.
• Nousiainen M, Silljé HH, Sauer G; et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Olsen JV, Blagoev B, Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
• Ewing RM, Chu P, Elisma F; et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.