DDX43

DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
Identifiers
Symbols	DDX43 ; CT13; HAGE
External IDs	OMIM: 606286 HomoloGene: 56814 GeneCards: DDX43 Gene
EC number	3.6.4.13
Gene ontology Molecular function • RNA binding • ATP-dependent RNA helicase activity • ATP binding Cellular component • intracellular Biological process • RNA secondary structure unwinding Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	55510	100048658
Ensembl	ENSG00000080007	ENSMUSG00000070291
UniProt	Q9NXZ2	D3YVE3
RefSeq (mRNA)	NM_018665	NM_001191044
RefSeq (protein)	NP_061135	NP_001177973
Location (UCSC)	Chr 6: 73.39 – 73.42 Mb	Chr 9: 78.4 – 78.42 Mb
PubMed search

Probable ATP-dependent RNA helicase DDX43 is an enzyme that in humans is encoded by the DDX43 gene.^[1][2]

Function

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD box family and displays tumor-specific expression.^[2]

References

1. Martelange V, De Smet C, De Plaen E, Lurquin C, Boon T (Aug 2000). "Identification on a human sarcoma of two new genes with tumor-specific expression". Cancer Res 60 (14): 3848–55. PMID 10919659.
2. "Entrez Gene: DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43".

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
• Nagel H, Laskawi R, Eiffert H, Schlott T (2003). "Analysis of the tumour suppressor genes, FHIT and WT-1, and the tumour rejection genes, BAGE, GAGE-1/2, HAGE, MAGE-1, and MAGE-3, in benign and malignant neoplasms of the salivary glands". MP, Mol. Pathol. 56 (4): 226–31. doi:10.1136/mp.56.4.226. PMC 1187325. PMID 12890744.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Mathieu MG, Knights AJ, Pawelec G, Riley CL, Wernet D, Lemonnier FA, Straten PT, Mueller L, Rees RC, McArdle SE (2007). "HAGE, a cancer/testis antigen with potential for melanoma immunotherapy: identification of several MHC class I/II HAGE-derived immunogenic peptides". Cancer Immunol. Immunother. 56 (12): 1885–95. doi:10.1007/s00262-007-0331-2. PMID 17487488.