DEC1

Deleted in esophageal cancer 1
Identifiers
Symbols	DEC1 ; CTS9
External IDs	OMIM: 604767 HomoloGene: 88845 GeneCards: DEC1 Gene
Gene ontology Biological process • negative regulation of cell proliferation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	50514	n/a
Ensembl	ENSG00000173077	n/a
UniProt	Q9P2X7	n/a
RefSeq (mRNA)	NM_017418	n/a
RefSeq (protein)	NP_059114	n/a
Location (UCSC)	Chr 9: 115.14 – 115.4 Mb	n/a
PubMed search		n/a

Deleted in esophageal cancer 1 is a protein that in humans is encoded by the DEC1 gene.^[1][2][3]

Function

The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas, associated with lymph node metastasis, and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas.^[3]

References

1. Miura K, Suzuki K, Tokino T, Isomura M, Inazawa J, Matsuno S, Nakamura Y (May 1996). "Detailed deletion mapping in squamous cell carcinomas of the esophagus narrows a region containing a putative tumor suppressor gene to about 200 kilobases on distal chromosome 9q". Cancer Res 56 (7): 1629–34. PMID 8603412.
2. Nishiwaki T, Daigo Y, Kawasoe T, Nakamura Y (Feb 2000). "Isolation and mutational analysis of a novel human cDNA, DEC1 (deleted in esophageal cancer 1), derived from the tumor suppressor locus in 9q32". Genes Chromosomes Cancer 27 (2): 169–76. doi:10.1002/(SICI)1098-2264(200002)27:2<169::AID-GCC8>3.0.CO;2-M. PMID 10612805.
3. "Entrez Gene: DEC1 deleted in esophageal cancer 1".

Further reading

• Qian Y, Zhang J, Yan B, Chen X (2008). "DEC1, a basic helix-loop-helix transcription factor and a novel target gene of the p53 family, mediates p53-dependent premature senescence.". J. Biol. Chem. 283 (5): 2896–905. doi:10.1074/jbc.M708624200. PMID 18025081.
• Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.". Int. J. Cancer 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723.
• Li Y, Xie M, Yang J, Yang D, Deng R, Wan Y, Yan B (2006). "The expression of antiapoptotic protein survivin is transcriptionally upregulated by DEC1 primarily through multiple sp1 binding sites in the proximal promoter.". Oncogene 25 (23): 3296–306. doi:10.1038/sj.onc.1209363. PMID 16462771.
• Preusser M, Birner P, Ambros IM, Ambros PF, Budka H, Harris AL, Hainfellner JA (2006). "DEC1 expression in 1p-aberrant oligodendroglial neoplasms.". Histol. Histopathol. 20 (4): 1173–7. PMID 16136500.
• Yang L, Leung AC, Ko JM, Lo PH, Tang JC, Srivastava G, Oshimura M, Stanbridge EJ, Daigo Y, Nakamura Y, Tang CM, Lau KW, Law S, Lung ML (2005). "Tumor suppressive role of a 2.4 Mb 9q33-q34 critical region and DEC1 in esophageal squamous cell carcinoma.". Oncogene 24 (4): 697–705. doi:10.1038/sj.onc.1208179. PMID 15580306.
• Wong VC, Ko JM, Qi RZ, Li PJ, Wang LD, Li JL, Chan YP, Chan KW, Stanbridge EJ, Lung ML (Mar 1, 2011). "Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis.". British Journal of Cancer 104 (5): 841–9. doi:10.1038/bjc.2011.25. PMID 21326238.
• Leung AC, Wong VC, Yang LC, Chan PL, Daigo Y, Nakamura Y, Qi RZ, Miller LD, Liu ET, Wang LD, Li JL, Law S, Tsao SW, Lung ML (Feb 1, 2008). "Frequent decreased expression of candidate tumor suppressor gene, DEC1, and its anchorage-independent growth properties and impact on global gene expression in esophageal carcinoma.". International Journal of Cancer. Journal International Du Cancer 122 (3): 587–94. doi:10.1002/ijc.23144. PMID 17943723.