DEF6
| DEF6 guanine nucleotide exchange factor | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | DEF6 ; IBP; SLAT; SWAP70L | ||||||||||
| External IDs | OMIM: 610094 MGI: 1346328 HomoloGene: 11103 GeneCards: DEF6 Gene | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
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| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 50619 | 23853 | |||||||||
| Ensembl | ENSG00000023892 | ENSMUSG00000002257 | |||||||||
| UniProt | Q9H4E7 | Q8C2K1 | |||||||||
| RefSeq (mRNA) | NM_022047 | NM_027185 | |||||||||
| RefSeq (protein) | NP_071330 | NP_081461 | |||||||||
| Location (UCSC) |
Chr 6: 35.3 – 35.32 Mb |
Chr 17: 28.21 – 28.23 Mb | |||||||||
| PubMed search | |||||||||||
Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene.[1][2]
References
- ↑ Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM (May 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". The Journal of Biological Chemistry 284 (18): 11882–91. doi:10.1074/jbc.M809712200. PMC 2673257. PMID 19251698.
- ↑ "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)".
Further reading
- Oka T, Ihara S, Fukui Y (Jan 2007). "Cooperation of DEF6 with activated Rac in regulating cell morphology". The Journal of Biological Chemistry 282 (3): 2011–8. doi:10.1074/jbc.M605153200. PMID 17121847.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F (Apr 2004). "DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA". Experimental Cell Research 294 (2): 335–44. doi:10.1016/j.yexcr.2003.12.004. PMID 15023524.
- Gupta S, Fanzo JC, Hu C, Cox D, Jang SY, Lee AE, Greenberg S, Pernis AB (Oct 2003). "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse". The Journal of Biological Chemistry 278 (44): 43541–9. doi:10.1074/jbc.M308960200. PMID 12923183.
- Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G, Pernis AB (Apr 2003). "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system". Human Immunology 64 (4): 389–401. doi:10.1016/S0198-8859(03)00024-7. PMID 12651066.
- Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A (Mar 2003). "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells". Immunity 18 (3): 403–14. doi:10.1016/S1074-7613(03)00054-2. PMID 12648457.
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