DEFA3

Defensin, alpha 3, neutrophil-specific

PDB rendering based on 1zmh.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1DFN, 1ZMH, 1ZMI, 1ZMK, 2PM4, 2PM5

Identifiers

Symbols

DEFA3 ; DEF3; HNP-3; HNP3; HP-3; HP3

External IDs

OMIM: 604522 HomoloGene: 128756 GeneCards: DEFA3 Gene

Gene ontology
Molecular function	• molecular_function
Cellular component	• extracellular region • extracellular space • Golgi lumen • azurophil granule lumen • extracellular exosome
Biological process	• innate immune response in mucosa • antibacterial humoral response • intracellular estrogen receptor signaling pathway • killing of cells of other organism • innate immune response • defense response to Gram-positive bacterium • defense response to fungus • defense response to virus
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_005217

n/a

RefSeq (protein)

NP_005208

n/a

Location (UCSC)

Chr 8:
7 – 7.02 Mb

n/a

PubMed search

n/a

Defensin, alpha 3 (DEFA3) also known as human alpha defensin 3, human neutrophil peptide 3 (HNP-3) or neutrophil defensin 3 is a human protein that is encoded by the DEFA3 gene.^[1] Human alpha defensin 3 belongs to the alpha defensin family of antimicrobial peptides.

Function

Defensins are a family of microbicidal and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 3, is found in the microbicidal granules of neutrophils and likely plays a role in phagocyte-mediated host defense. Several alpha defensin genes are clustered on chromosome 8. This gene differs from defensin, alpha 1 by only one amino acid. This gene and the gene encoding defensin, alpha 1 are both subject to copy number variation.^[1]

References

1 2 "Entrez Gene: defensin".

Kocsis AK, Ocsovszky I, Tiszlavicz L; et al. (2009). "Helicobacter pylori induces the release of alpha-defensin by human granulocytes.". Inflamm. Res. 58 (5): 241–7. doi:10.1007/s00011-008-8100-z. PMID 19169650.
Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Aldred PM, Hollox EJ, Armour JA (2005). "Copy number polymorphism and expression level variation of the human alpha-defensin genes DEFA1 and DEFA3.". Hum. Mol. Genet. 14 (14): 2045–52. doi:10.1093/hmg/ddi209. PMID 15944200.

PDB gallery

1zmh: Crystal structure of human neutrophil peptide 2, HNP-2 (variant Gly16-> D-Ala)

1zmk: Crystal structure of human alpha-defensin-2 (variant Gly16-> D-ALA), P 42 21 2 space group

2pm4: Human alpha-defensin 1 (multiple Arg->Lys mutant)

2pm5: Human alpha-defensin 1 derivative (HNP1)

1dfn: CRYSTAL STRUCTURE OF DEFENSIN HNP-3, AN AMPHIPHILIC DIMER: MECHANISMS OF MEMBRANE PERMEABILIZATION

2pm1: Derivative of human alpha-defensin 1 (HNP1)

1zmi: Crystal structure of human alpha_defensin-2 (variant GLY16->D-ALA), P 32 2 1 space group )

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article is issued from Wikipedia - version of the Tuesday, May 05, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

DEFA3

Function

References

Further reading