DEFB105A
| Defensin, beta 105A | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | DEFB105A ; BD-5; DEFB-5; DEFB105 | ||||||||||
| External IDs | MGI: 1924924 HomoloGene: 17531 GeneCards: DEFB105A Gene | ||||||||||
| |||||||||||
| Orthologs | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | 245908 | 77674 | |||||||||
| Ensembl | ENSG00000186562 | ENSMUSG00000043787 | |||||||||
| UniProt | Q8NG35 | Q8K4N3 | |||||||||
| RefSeq (mRNA) | NM_152250 | NM_152802 | |||||||||
| RefSeq (protein) | NP_689463 | NP_690015 | |||||||||
| Location (UCSC) |
Chr 8: 7.82 – 7.82 Mb |
Chr 8: 19.11 – 19.11 Mb | |||||||||
| PubMed search | |||||||||||
Beta-defensin 105 is a protein that in humans is encoded by the DEFB105A gene.[1][2][3]
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 105, DEFB105A and DEFB105B, in tail-to-tail orientation. This gene, DEFB105A, represents the more centromeric copy.[3]
References
- ↑ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
- ↑ Semple CA, Rolfe M, Dorin JR (May 2003). "Duplication and selection in the evolution of primate beta-defensin genes". Genome Biol 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587. PMID 12734011.
- 1 2 "Entrez Gene: DEFB105A defensin, beta 105A".
Further reading
- Patil AA, Cai Y, Sang Y; et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.". Physiol. Genomics 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865.
- Boniotto M, Ventura M, Eskdale J; et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
- Taudien S, Galgoczy P, Huse K; et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.". BMC Genomics 5 (1): 92. doi:10.1186/1471-2164-5-92. PMC 544879. PMID 15588320.
- Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC 1180683. PMID 12916016.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Yamaguchi Y, Nagase T, Makita R; et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.". J. Immunol. 169 (5): 2516–23. doi:10.4049/jimmunol.169.5.2516. PMID 12193721.
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