DEFB106A
| Defensin, beta 106A | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | DEFB106A ; BD-6; DEFB-6; DEFB106 | ||||||||||||
| External IDs | MGI: 2179202 HomoloGene: 134659 GeneCards: DEFB106A Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 245909 | 246082 | |||||||||||
| Ensembl | ENSG00000186579 | ENSMUSG00000048500 | |||||||||||
| UniProt | Q8N104 | Q8R2I5 | |||||||||||
| RefSeq (mRNA) | NM_152251 | NM_139222 | |||||||||||
| RefSeq (protein) | NP_689464 | NP_631968 | |||||||||||
| Location (UCSC) |
Chr 8: 7.83 – 7.83 Mb |
Chr 8: 21.93 – 21.93 Mb | |||||||||||
| PubMed search | |||||||||||||
Beta-defensin 106 is a protein that in humans is encoded by the DEFB106A gene.[1][2]
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 106, DEFB106A and DEFB106B, in head-to-head orientation. This gene, DEFB106A, represents the more centromeric copy.[2]
Function
The purified DEFB106 showed antimicrobial activity against Escherichia coli, Candida albicans and Staphylococcus aureus.[3]
References
- ↑ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved beta -defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
- 1 2 "Entrez Gene: DEFB106A defensin, beta 106A".
- ↑ Xin A (Jan 2014). "Soluble fusion expression, characterization and localization of human β-defensin 6...". J Mol Med Rep 9 (1): 149–55. doi:10.3892/mmr.2013.1768. PMID 24189797.
Further reading
- Yamaguchi Y, Nagase T, Makita R; et al. (2002). "Identification of multiple novel epididymis-specific beta-defensin isoforms in humans and mice.". J. Immunol. 169 (5): 2516–23. doi:10.4049/jimmunol.169.5.2516. PMID 12193721.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes.". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. doi:10.1165/rcmb.2002-0205OC. PMID 12600824.
- Semple CA, Rolfe M, Dorin JR (2003). "Duplication and selection in the evolution of primate beta-defensin genes.". Genome Biol. 4 (5): R31. doi:10.1186/gb-2003-4-5-r31. PMC 156587. PMID 12734011.
- Hollox EJ, Armour JA, Barber JC (2003). "Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster.". Am. J. Hum. Genet. 73 (3): 591–600. doi:10.1086/378157. PMC 1180683. PMID 12916016.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Taudien S, Galgoczy P, Huse K; et al. (2006). "Polymorphic segmental duplications at 8p23.1 challenge the determination of individual defensin gene repertoires and the assembly of a contiguous human reference sequence.". BMC Genomics 5 (1): 92. doi:10.1186/1471-2164-5-92. PMC 544879. PMID 15588320.
- Boniotto M, Ventura M, Eskdale J; et al. (2005). "Evidence for duplication of the human defensin gene DEFB4 in chromosomal region 8p22-23 and implications for the analysis of SNP allele distribution.". Genet. Test. 8 (3): 325–7. doi:10.1089/gte.2004.8.325. PMID 15727258.
- Patil AA, Cai Y, Sang Y; et al. (2006). "Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract.". Physiol. Genomics 23 (1): 5–17. doi:10.1152/physiolgenomics.00104.2005. PMID 16033865.
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