DGKB
| Diacylglycerol kinase, beta 90kDa | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | DGKB ; DAGK2; DGK; DGK-BETA | ||||||||||||
| External IDs | OMIM: 604070 MGI: 2442474 HomoloGene: 37875 GeneCards: DGKB Gene | ||||||||||||
| EC number | 2.7.1.107 | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 1607 | 217480 | |||||||||||
| Ensembl | ENSG00000136267 | ENSMUSG00000036095 | |||||||||||
| UniProt | Q9Y6T7 | Q6NS52 | |||||||||||
| RefSeq (mRNA) | NM_004080 | NM_178681 | |||||||||||
| RefSeq (protein) | NP_004071 | NP_848796 | |||||||||||
| Location (UCSC) |
Chr 7: 14.15 – 14.97 Mb |
Chr 12: 37.88 – 38.63 Mb | |||||||||||
| PubMed search | |||||||||||||
Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene.[1][2]
Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have been found for this gene.[2]
References
- ↑ Goto K, Kondo H (Sep 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes in neurons". Proc Natl Acad Sci U S A 90 (16): 7598–602. doi:10.1073/pnas.90.16.7598. PMC 47189. PMID 7689223.
- 1 2 "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa".
Further reading
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Caricasole A, Bettini E, Sala C, et al. (2002). "Molecular cloning and characterization of the human diacylglycerol kinase beta (DGKbeta) gene: alternative splicing generates DGKbeta isotypes with different properties". J. Biol. Chem. 277 (7): 4790–6. doi:10.1074/jbc.M110249200. PMID 11719522.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
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