DGKD

Diacylglycerol kinase, delta 130kDa
PDB rendering based on 1r79.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1R79​, 3BQ7​
Identifiers
Symbols	DGKD ; DGKdelta; dgkd-2
External IDs	OMIM: 601826 HomoloGene: 100054 ChEMBL: 1075120 GeneCards: DGKD Gene
EC number	2.7.1.107
Gene ontology Molecular function • diacylglycerol kinase activity • protein binding • ATP binding • diacylglycerol binding • protein homodimerization activity • metal ion binding • protein heterodimerization activity Cellular component • cytoplasm • plasma membrane • cytoplasmic membrane-bounded vesicle Biological process • endocytosis • signal transduction • epidermal growth factor receptor signaling pathway • protein kinase C-activating G-protein coupled receptor signaling pathway • multicellular organismal development • blood coagulation • response to organic substance • protein transport • cell growth • phosphorylation • second-messenger-mediated signaling • platelet activation • diacylglycerol metabolic process • protein homooligomerization Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	8527	227333
Ensembl	ENSG00000077044	ENSMUSG00000070738
UniProt	Q16760	E9PUQ8
RefSeq (mRNA)	NM_003648	NM_177646
RefSeq (protein)	NP_003639	NP_808314
Location (UCSC)	Chr 2: 233.35 – 233.47 Mb	Chr 1: 87.85 – 87.95 Mb
PubMed search

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.^[1][2][3]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.^[3]

References

1. Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
2. Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723.
3. "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa".

Further reading

• Nagase T, Seki N, Tanaka A; et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
• Bregoli L, Baldassare JJ, Raben DM (2001). "Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin.". J. Biol. Chem. 276 (26): 23288–95. doi:10.1074/jbc.M101501200. PMID 11309392.
• Nagaya H, Wada I, Jia YJ, Kanoh H (2002). "Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains.". Mol. Biol. Cell 13 (1): 302–16. doi:10.1091/mbc.01-05-0255. PMC 65090. PMID 11809841.
• Imai S, Sakane F, Kanoh H (2002). "Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation.". J. Biol. Chem. 277 (38): 35323–32. doi:10.1074/jbc.M202035200. PMID 12084710.
• Sakane F, Imai S, Yamada K; et al. (2003). "Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions.". J. Biol. Chem. 277 (45): 43519–26. doi:10.1074/jbc.M206895200. PMID 12200442.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Imai S, Kai M, Yamada K; et al. (2005). "The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain.". Biochem. J. 382 (Pt 3): 957–66. doi:10.1042/BJ20040681. PMC 1133971. PMID 15228384.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Leach NT, Sun Y, Michaud S; et al. (2007). "Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice.". Am. J. Hum. Genet. 80 (4): 792–9. doi:10.1086/513019. PMC 1852716. PMID 17357084.