DHRS3

Dehydrogenase/reductase (SDR family) member 3
Identifiers
Symbols	DHRS3 ; DD83.1; RDH17; Rsdr1; SDR1; SDR16C1; retSDR1
External IDs	OMIM: 612830 MGI: 1315215 HomoloGene: 20994 GeneCards: DHRS3 Gene
EC number	1.1.1.300
Gene ontology Molecular function • nucleotide binding • retinol dehydrogenase activity • electron carrier activity • NADP-retinol dehydrogenase activity Cellular component • endoplasmic reticulum membrane • integral component of membrane • photoreceptor outer segment membrane Biological process • retinoid metabolic process • outflow tract morphogenesis • visual perception • phototransduction, visible light • regulation of ossification • retinol metabolic process • negative regulation of retinoic acid receptor signaling pathway • oxidation-reduction process • palate development • bone morphogenesis • cardiac septum morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9249	20148
Ensembl	ENSG00000162496	ENSMUSG00000066026
UniProt	O75911	O88876
RefSeq (mRNA)	NM_004753	NM_001172424
RefSeq (protein)	NP_004744	NP_001165895
Location (UCSC)	Chr 1: 12.57 – 12.62 Mb	Chr 4: 144.89 – 144.93 Mb
PubMed search

Short-chain dehydrogenase/reductase 3 is an enzyme that in humans is encoded by the DHRS3 gene.^[1][2][3][4]

References

1. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K (Sep 1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". J Biol Chem 273 (34): 21790–9. doi:10.1074/jbc.273.34.21790. PMID 9705317.
2. Haeseleer F, Jang GF, Imanishi Y, Driessen CA, Matsumura M, Nelson PS, Palczewski K (Nov 2002). "Dual-substrate Specificity Short Chain Retinol Dehydrogenases from the Vertebrate Retina". J Biol Chem 277 (47): 45537–46. doi:10.1074/jbc.M208882200. PMC 1435693. PMID 12226107.
3. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
4. "Entrez Gene: DHRS3 dehydrogenase/reductase (SDR family) member 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Cerignoli F, Guo X, Cardinali B; et al. (2002). "retSDR1, a short-chain retinol dehydrogenase/reductase, is retinoic acid-inducible and frequently deleted in human neuroblastoma cell lines". Cancer Res. 62 (4): 1196–204. PMID 11861404.
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E; et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Gregory SG, Barlow KF, McLay KE; et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
• Roni V, Carpio R, Wissinger B (2007). "Mapping of transcription start sites of human retina expressed genes". BMC Genomics 8: 42. doi:10.1186/1471-2164-8-42. PMC 1802077. PMID 17286855.